A Study on the Impact of Temperature on the Anchoring Durability of Carbon-Fiber-Reinforced Polymer Cables.

To improve the application of carbon-fiber-reinforced polymers (CFRPs) in civil engineering, the long-term durability of CFRP anchorage systems has become a critical issue. Temperature fluctuations can significantly impact the bond performance between CFRPs and the load transfer medium (LTM), making it essential to understand the effects of temperature on the durability of CFRP anchorages. Therefore, this study investigates the influence of temperature on the durability of CFRP anchorages through aging tests on 30 epoxy-filled CFRP-bonded anchorage specimens, followed by pull-out tests.

Cognitive impairment in Alzheimer's disease FAD mouse model: Synaptic loss facilitated by activated microglia via C1qA.

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder characterized by cognitive dysfunction. The connection between neuroinflammation and abnormal synaptic function in AD is recognized, but the underlying mechanisms remain unclear. In this study, we utilized a mouse model of AD, FAD mice aged 6-7 months, to investigate the molecular changes affecting cognitive impairment.

A Nano Drug Delivery System Based on Polysaccharide for Combination of Chemotherapy and Immunotherapy.

Combination of chemotherapy and immunotherapy has been a promising strategy in cancer treatment. Polysaccharides from (AP), a well-known Chinese herbal medicine, have been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive tumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide) was constructed.

miR-320/VEGFA axis affects high glucose-induced metabolic memory during human umbilical vein endothelial cell dysfunction in diabetes pathology.

The "metabolic memory", a phenomenon that the target cell remembers the early hyperglycemia, has been reported to be a critical issue in diabetes pathogenesis. Here, we confirmed the inducible effects of high glucose (HG) and HG followed by normal glucose (HN) upon the proliferation and the tube formation capacity of human umbilical vein endothelial cells (HUVECs), as well as the suppressive effects of HG and HN on HUVEC apoptosis. In the meantime, the miR-320 expression could be dramatically downregulated (** and ## P < 0.