Discovery of -(2-Acetamidobenzo[]thiazol-6-yl)-2-phenoxyacetamide Derivatives as Novel Potential BCR-ABL1 Inhibitors Through Structure-Based Virtual Screening.

BCR-ABL1 kinase is a critical driver of chronic myeloid leukemia (CML) pathophysiology. The approval of allosteric inhibitor asciminib brings new hope for overcoming drug resistance caused by mutations in the ATP-binding site. To expand the chemical diversity of BCR-ABL1 kinase inhibitors with positive anti-tumor effect with asciminib, structure-based virtual screening and molecular dynamics simulations were employed to discover novel scaffolds.

Research on the status and influencing factors of maternal health literacy among postpartum women in urban villages.

Aim: To comprehensively identify the status and influencing factors on maternal health literacy among postpartum women in Guangzhou urban villages.

Design: An explanatory sequential mixed-method research was conducted from November 2021 to July 2022.

Methods: The quantitative survey was conducted among postpartum women in Guangzhou urban villages using the convenience sampling principle, and a questionnaire survey was used to reflect the status and influencing factors on maternal health literacy.

Effect of mode of delivery on postpartum weight retention: A systematic review and meta-analysis.

Objective: Retention of weight gained over pregnancy increases the risk of long-term obesity and related health concerns. While many risk factors for this postpartum weight retention have been examined, the role of mode of delivery in this relationship remains controversial. We carried out a systematic review and meta-analysis to determine the effect of mode of delivery on postpartum weight retention.

The interplay between stigma and sleep quality in breast cancer: A cross-sectional network analysis.

Purpose: Stigma, a subjective internal shame, arises from the association of cancer with death. Sleep quality can be considered a product of stigma. However, the extent of overlap or difference between the two remains unclear.

CCR5 promoter polymorphisms associated with nonsmall cell lung cancer.

C-C chemokine receptor 5 (CCR5) plays a crucial role in the regulation of immune cell activation and migration as well as the progression of many cancers. We performed an in silico analysis using public data resources and found that the lung cancer patients with higher CCR5 expression had a notably better overall survival than those with lower CCR5 expression patients and CCR5 expression level is positive correlated with the infiltration of immune cells, such as B, CD8 T and CD4 T cells, in both lung adenocarcinoma and lung squamous cell cancer. In the present study, we investigated the association between the promoter polymorphism of CCR5 and nonsmall cell lung cancer (NSCLC).

Association between stigma and sleep quality in patients with breast cancer: A latent profile and mediation analysis.

Purpose: This study aims to identify the heterogeneity in the stigma experienced by patients with breast cancer and examine the mediation effect of resilience on the relation between stigma and sleep quality.

Method: A total of 396 patients with breast cancer were enrolled from Be Resilient to Breast Cancer (BRBC) program between January and April 2023. Participants completed the Social Impact Scale, the 10-item Connor-Davidson Resilience Scale, and the Pittsburgh Sleep Quality Index Scale.

Gene Polymorphisms Increase the Susceptibility to Tuberculosis.

Purpose: Tuberculosis (TB) is known to result from a complex interaction between the host immune response and infection. The transporter associated with antigen processing (TAP) plays an important role in the processing and presentation pathways for the () antigen. To investigate the possible association of the and genes with TB.

Molecular Profiling Reveals Common and Specific Development Processes in Different Types of Gynecologic Cancers.

Background: Gynecologic cancers have become a major threat to women's health. The molecular biology of gynecologic cancers is not as well understood as that of breast cancer, and precision targeting is still new. Although viewed collectively as a group of cancers within the female reproductive system, they are more often studied separately.

Dynamic analysis of m6A methylation spectroscopy during progression and reversal of hepatic fibrosis.

To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection of CCl4.

Exposure to air pollution and scarlet fever resurgence in China: a six-year surveillance study.

Scarlet fever has resurged in China starting in 2011, and the environment is one of the potential reasons. Nationwide data on 655,039 scarlet fever cases and six air pollutants were retrieved. Exposure risks were evaluated by multivariate distributed lag nonlinear models and a meta-regression model.

Knowledge, Attitudes, Preventive Practices and Screening Intention about Colorectal Cancer and the Related Factors among Residents in Guangzhou, China.

Background: In Guangzhou, China, colorectal cancer (CRC) is the second most commonly diagnosed cancer. The government initiated a CRC screening program in 2015, and investigating the knowledge, attitudes, and practices toward CRC would help facilitate the participation of the program. Methods: A cross-sectional survey was conducted from October 2014 to September 2015.

Associations of Epstein-Barr Virus DNA in PBMCs and the Subtypes with Breast Cancer Risk.

Epstein-Barr virus (EBV) has been found to be implicated in the development of breast cancer. The purpose of the present study was to identify the associations of EBV DNA and the subtypes in peripheral blood mononuclear cells (PBMCs) with the risk of breast cancer. A case-control study with 671 breast cancer cases and 859 age-matched controls was conducted in Guangzhou, China.

Biological characteristics and construction of stable ALDH-1 knock-down Hela cell lines.

Objectives: To explore the relationship between aldehye dehydrogenase-1 (ALDH-1) and biological characteristics of the stable ALDH-1 knock-down Hela cell lines.

Materials And Methods: Transfected Hela cells with lentiviral vector were utilized and puromycin was used to screen and achieve the stable cell lines. The interference efficiency was calculated by performing qRT-PCR to detect the expression of ALDH-1 of three groups including the interfering group, the negative control (NC) group, and the normal Hela group.

APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer.

Cervical cancer is the second most common cancer among women worldwide and is the leading cause of deaths in developing countries. Persistent infections with a subset of HPVs, called "high-risk HPVs", including HPV16 and HPV18, are the primary cause of cervical cancer. The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of proteins is a group of cellular enzymes that catalyze the deamination of cytidine (C) to uracil (U) in single-stranded DNA/RNA, and functions as antiviral factors in the innate immune system of the host.

[Analysis of phthalate esters in plastic-packaging bags on-line sample stacking-microemulsion electrokinetic chromatography].

Two convenient, effective, and reproducible methods using microemulsion electrokinetic chromatography (MEEKC)-normal stacking mode (NSM) and reversed electrode polarity stacking mode (REPSM) were developed for the on-line sample stacking of phthalate esters (PAEs). REPSM coupled with MEEKC increased the sensitivity of 937.5 to 7,143 times for four PAEs compared to the conventional MEEKC.