Flexible Neural Probes with Optical Artifact-Suppressing Modification and Biofriendly Polypeptide Coating.

The advent of optogenetics provides a well-targeted tool to manipulate neurons because of its high time resolution and cell-type specificity. Recently, closed-loop neural manipulation techniques consisting of optical stimulation and electrical recording have been widely used. However, metal microelectrodes exposed to light radiation could generate photoelectric noise, thus causing loss or distortion of neural signal in recording channels.

Enhancement effect of geniposide on solubility and intestinal absorption of baicalin.

Geniposide and baicalin, the main components of Huangqin-Zhizi herb pair, have been combined to increase the efficacy. To reveal the underlying compatibility mechanism of these two components, the synergistic effects of geniposide on the enhancement of solubility, apparent oil-water partition coefficient, and intestinal absorption of baicalin were investigated. The equilibrium solubility and apparent oil-water partition coefficient of baicalin in different solvents were determined through the shake-flask and high-performance liquid chromatography with diode array detection methods.

A simplified and miniaturized glucometer-based assay for the detection of β-glucosidase activity.

β-Glucosidase activity assays constitute an important indicator for the early diagnosis of neonatal necrotizing enterocolitis and qualitative changes in medicinal plants. The drawbacks of the existing methods are high consumption of both time and reagents, complexity in operation, and requirement of expensive instruments and highly trained personnel. The present study provides a simplified, highly selective, and miniaturized glucometer-based strategy for the detection of β-glucosidase activity.

Simultaneous determination of dihydromyricetin and resveratrol in Ampelopsis sinica (Miq.) W.T. Wang by high-performance liquid chromatography coupled with a diode array detection method.

Yeputaoteng is the dried ground part of Ampelopsis sinica (Miq.) W.T.