Publications by authors named "Minxia Xiu"
Article Synopsis
- Parkinson's disease involves the degeneration of dopamine systems, leading to worsening motor and nonmotor symptoms, primarily affecting the basal ganglia.
- Recent research highlights the zona incerta (ZI) as a significant target for therapies like subthalamotomy and deep brain stimulation (DBS), which have shown promise in improving symptoms like rigidity, tremors, and even nonmotor issues like pain and anxiety.
- Animal studies utilizing advanced techniques reveal the critical roles of different neuron types in the ZI and their effects on movement and coordination, indicating a need for further exploration and discussion of controversies in the field.
Various pharmacological blockers targeting K channel have been identified to be related to the treatment of Parkinson's disease (PD). Previous studies showed that 4-Aminopyridine (4-AP), a wide-spectrum K channel blocker, was able to attenuate apomorphine-induced rotation in parkinsonism rats, indicating the possible beneficial effects in attenuation of PD motor symptoms. However, it is unclear whether 4-AP exhibits neuroprotective effects against the neurodegeneration of substantia nigra (SN)-striatum system in PD.
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