Publications by authors named "Minxi Duan"
Neurobiol Aging
November 2024
Article Synopsis
- - The study investigates how the APOE4 genetic variant interacts with plasma metabolites to affect white matter (WM) integrity in older adults, using data from 1917 participants aged 65-81.
- - While no direct association was found between APOE4 or metabolites and WM integrity, significant interactions were observed. Specifically, certain lipoproteins were linked to decreased WM integrity in APOE4 carriers but showed a positive association in non-carriers.
- - The findings highlight the complex role of APOE4 in moderating the effects of metabolic factors on brain health, suggesting that people with this genetic risk factor may experience unique vulnerabilities regarding white matter integrity.
