Publications by authors named "Minutoli L"
The journal retracts the article titled "Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity" [...
View Article and Find Full Text PDFPurpose: This literature review synthetizes current evidence on the timing and efficacy of dexamethasone intravitreal injections for diabetic macular edema (DME) in patients undergoing cataract surgery, particularly phacoemulsification, to determine the optimal timing for improved outcome.
Methods: A systematic review of the literature was conducted across key databases to identify peer-reviewed studies, clinical trials, and meta-analyses addressing dexamethasone injections administered pre-, intra-, and post-operatively for DME in the context of cataract surgery. Studies were selected based on relevance to timing, visual outcomes, and inflammation control, with a focus on comparative efficacy.
Article Synopsis
- Obesity is a key risk factor for cardiovascular diseases, and the study investigates the anti-obesity effects of lycopene (LYC) and fruit extract (GE) on adipocytes and Zucker rats.
- The research shows that LYC and GE significantly enhance thermogenic gene expression, reduce lipid droplet size, and promote adipocyte remodeling in treated groups.
- Combining LYC and GE leads to improved weight management and decreased food intake, suggesting their potential as effective components in obesity therapies.
Article Synopsis
- * The research investigated the impact of cadmium chloride (CdCl) on chondrocyte viability and gene expression, finding that higher doses resulted in reduced cell survival and increased markers of cell death.
- * Seleno-methionine (Se-Met) was shown to protect chondrocytes from CdCl damage by improving cell survival and reducing harmful gene expression, suggesting dietary interventions may help mitigate the effects of toxic environmental pollutants.
An acute metabolic complication of diabetes mellitus, especially type 1, is diabetic ketoacidosis (DKA), which is due to an increase in blood ketone concentrations. Sodium/glucose co-transporter-2 inhibitor (SGLT2-i) drugs have been associated with the occurrence of a particular type of DKA defined as euglycemic (euDKA), characterized by glycemic levels below 300 mg/dL. A fair number of euDKA cases in SGLT2-i-treated patients have been described, especially in the last few years when there has been a significant increased use of these drugs.
View Article and Find Full Text PDFGlioblastoma is the most common malignant primary tumor of the CNS. The prognosis is dismal, with a median survival of 15 months. Surgical treatment followed by adjuvant therapies such as radiotherapy and chemotherapy characterize the classical strategy.
View Article and Find Full Text PDFPurpose: Aim of the study was to evaluate the efficacy of dexamethasone (DEX) 0.7 mg intravitreal implant in patients with diabetic macular edema (DME) and serous retinal detachment (SRD), and to study the prognostic factors on a follow up of 12 months.
Methods: Forty eyes of twenty- six patients with centre involving DME and SRD, who underwent DEX implant, were enrolled.
Article Synopsis
- * The study investigated β-Caryophyllene (BCP), a cannabinoid that activates the CB2 receptor, for its potential protective effects against Cd-induced toxicity in neuroblastoma SH-SY5Y cells, showing BCP's antioxidant, anti-inflammatory, and neuroprotective properties.
- * Results revealed that BCP treatment significantly reduced ROS accumulation and increased the expression of a key antioxidant protein, Nrf2, while also protecting cells from death and regulating inflammatory responses, suggesting BCP could be
Recently, an increase in the incidence of brain tumors has been observed in the most industrialized countries. This event triggered considerable interest in the study of heavy metals and their presence in the environment (air, water, soil, and food). It is probable that their accumulation in the body could lead to a high risk of the onset of numerous pathologies, including brain tumors, in humans.
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- Research has shown that natural substances like selenium (Se) and lycopene may help reduce male infertility caused by varicocele, with each having a positive effect individually.
- In a study with male rats, those with varicocele showed decreased testosterone levels, testicular weight, and structural damage in testicular tissues, indicating infertility issues.
- When treated with Se, lycopene, or both, the rats demonstrated significant improvements in testis weight, testosterone levels, and overall testicular health, suggesting that combining these nutrients could be a potential therapeutic approach alongside surgery, although more research is needed.
Article Synopsis
- Increased production of reactive oxygen species (ROS) during cellular injury can lead to conditions like cancer, with glutathione (GSH) playing a crucial role in restoring cellular balance.
- A review of clinical and preclinical data revealed that GSH can interact with anti-cancer drugs, either reducing their harmful effects or, conversely, increasing their toxicity through bioactivation.
- While many cancer patients self-prescribe GSH to mitigate treatment side effects, there’s limited scientific backing for its effectiveness, and it's recommended to use GSH only under medical guidance for safe administration.
Article Synopsis
- * Research has identified several mechanisms of Cd-induced kidney injury, including inflammation, programmed cell death, and hormonal imbalances, which can contribute to skeletal fragility as well.
- * Emerging evidence suggests that dietary factors, particularly nutraceuticals found in the Mediterranean diet, may offer safe therapeutic options to counteract Cd’s harmful effects and improve CKD management.
Multiple myeloma (MM) is malignant disease characterized by the clonal proliferation of plasma cells in the bone marrow, leading to anemia, immunosuppression, and other symptoms, that is generally hard to treat. In MM, the immune system is likely exposed to neoplasia-associated neoantigens for several years before the tumor onset. Different types of neoantigens have been identified.
View Article and Find Full Text PDFCardiac fibrosis is a pathological process characterized by an excessive deposition of extracellular matrix (ECM) and an increased production of fibrillar collagen in the cardiac interstitium, mainly caused by the activation of cardiac fibroblasts and their transition into myofibroblasts. Oxidative stress is deeply implicated in the pathogenesis of cardiac fibrosis both directly and via its involvement in the tumor growth factor β1 (TGF-β1) signaling. Ellagic acid (EA) and punicic acid (PA) are the main components of the Punica granatum L (pomegranate) fruit and seed oil respectively, whose antioxidant, anti-inflammatory and anti-fibrotic effects have been previously described.
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- Epilepsy affects about 1% of the global population, with 20%-30% of patients not achieving seizure control despite treatment with antiepileptic drugs (AEDs).
- Factors contributing to AED resistance include genetics, age, ethnicity, and other lifestyle factors like alcohol abuse.
- Research indicates that specific genetic variations (SNPs) in certain drug metabolism and transport genes can influence how well AEDs work, suggesting that genetic testing could help tailor more effective treatments for epilepsy patients.
Cardiac fibrosis is a common pathological feature of different cardiovascular diseases, characterized by the aberrant deposition of extracellular matrix (ECM) proteins in the cardiac interstitium, myofibroblast differentiation and increased fibrillar collagen deposition stimulated by transforming growth factor (TGF)-β activation. Biglycan (BGN), a small leucine-rich proteoglycan (SLRPG) integrated within the ECM, plays a key role in matrix assembly and the phenotypic control of cardiac fibroblasts. Moreover, BGN is critically involved in pathological cardiac remodeling through TGF-β binding, thus causing myofibroblast differentiation and proliferation.
View Article and Find Full Text PDFVaricocele is one of the main causes of infertility in men, thus representing an important clinical problem worldwide. Inflammation contributes mainly to its pathogenesis, even if the exact pathophysiological mechanisms that correlate varicocele and infertility are still unknown. In addition, oxidative stress, apoptosis, hypoxia, and scrotal hyperthermia seem to play important roles.
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