Publications by authors named "Minsi Zhou"

Objectives: Early-onset schizophrenia (EOS) is a severe and chronic mental disease that manifests during childhood and adolescence. There are currently no objective biomarkers to diagnose this psychosis. Recent research has shown that metabolic disorders are closely associated with the onset of schizophrenia, but there is a lack of evidence among children and adolescent populations.

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Background: Depression commonly co-occurs with inflammatory bowel disease (IBD). Abnormal glutamate levels in the insula and altered plasma inflammatory biomarkers are observed in IBD and depression. However, the changes in glutamate concentrations in insular subregions in IBD and their relationship with depression and inflammatory markers remain unclear.

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Particle-enhanced turbidimetric immunoassay (PETIA) is a new measurement procedure for detecting fecal calprotectin (FC). We aimed to investigate the accuracy and clinical performance of PETIA for FC. We assessed the accuracy of PETIA for FC measurements through concordance analysis, Passing-Bablok regression and Bland-Altman analysis, using enzyme-linked immunosorbent assay (ELISA) as the reference.

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Objectives: Emerging evidence suggests a potential relationship between body composition and short-term prognosis of ulcerative colitis (UC). Early and accurate assessment of rapid remission based on conventional therapy via abdominal computed tomography (CT) images has rarely been investigated. This study aimed to build a prediction model using CT-based body composition parameters for UC risk stratification.

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Objective(s): The prognostic value of systemic cytokine profiles and inflammatory markers in colorectal cancer were explored by several studies. We want to know more about inflammatory biomarkers in colorectal adenoma and early cancer.

Method: The level of 38 inflammatory markers in the plasma of 112 adenoma patients, 72 Tis-T1 staging of colorectal carcinoma patients, 34 T2-T4 staging of colorectal carcinoma patients and 53 normal subjects were detected and compared.

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Article Synopsis
  • Eosinophils are key players in causing inflammation and tissue damage in eosinophilic gastrointestinal diseases (EGIDs), and this study explores the role of the OX40 pathway in regulating these cells.
  • The researchers found that OX40 expression is elevated in eosinophils from EGE mice, which correlates with increased inflammation and production of specific cytokines.
  • Blocking OX40 showed promise in reducing eosinophil activation and inflammation, highlighting its potential as a target for treating allergic gastrointestinal conditions.
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ETV5 is an ETS transcription factor that has been associated with obesity in genomic association studies. However, little is known about the role of ETV5 in hepatic lipid metabolism and nonalcoholic fatty liver disease. In the current study, we found that ETV5 protein expression was increased in diet- and genetically induced steatotic liver.

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ZnT8 is a zinc transporter enriched in pancreatic β-cells, and its polymorphism is associated with increased susceptibility to type 2 diabetes. However, the exact role of ZnT8 in systemic energy metabolism remains elusive. In this study, we found that ZnT8 knockout mice displayed increased adiposity without obvious weight gain.

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Synopsis of recent research by authors named "Minsi Zhou"

  • - Minsi Zhou's recent research primarily focuses on the clinical performance of diagnostic assays and their implications for gastrointestinal disorders, particularly in relation to inflammatory markers and body composition in conditions like ulcerative colitis and colorectal cancer.
  • - Findings from Zhou’s studies indicate that the particle-enhanced turbidimetric immunoassay (PETIA) demonstrates promising accuracy for detecting fecal calprotectin, while CT-based body composition serves as a predictive tool for short-term prognosis in ulcerative colitis patients.
  • - Zhou also explores the role of inflammatory markers and gene expression in various metabolic and gastrointestinal diseases, revealing significant associations between these markers and conditions such as colorectal neoplasms and eosinophilic gastroenteritis, furthering the understanding of disease mechanisms and potential therapeutic targets.

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