Vascular endothelial growth factor is increased by human pulmonary cells stimulated with Dermatophagoides sp. extract.

Airway remodeling may lead to increased secretion of TGF-beta. TGF-beta is known to activate fibroblasts and to stimulate the secretion of vascular endothelial growth factor (VEGF). Soluble and cell-associated VEGF have been identified in subjects with chronic severe asthma.