Mastering seismic time series response predictions using an attention-Mamba transformer model for bridge bearings and piers across varied testing conditions.

This research introduces an advanced method for predicting seismic responses and hysteresis curves of instrumented bridge piers and bearings under various loading conditions, leaning solely on a single deep learning architecture and the same hyperparameters tuning. Test specimens are subjected to ground accelerations including vertical seismic loads and axial forces. To accurately capture peak values, particularly on the negative side of the hysteresis loop (unloading region), the model employs a stacked deep architecture.

Systematic identification of a synthetic lethal interaction in brain-metastatic lung adenocarcinoma.

Metastatic lung adenocarcinoma (LuAC) presents a significant clinical challenge due to the short latency and the lack of efficient treatment options. Therefore, identification of molecular vulnerabilities in metastatic LuAC holds great importance in the development of therapeutic drugs against this disease. In this study, we performed a genome-wide siRNA screening using poorly and highly brain-metastatic LuAC cell lines.

Deformable Photonic Crystals Based on Chiral Liquid Crystals with Thermal-Mediative Shape Memory Effect.

We propose a deformable photonic crystal that exhibits the thermal-mediative shape memory effect. The chiral liquid crystalline polymeric scaffold, which produces the structural colors from a helical twist of the liquid crystal director, is prepared through phase-stabilization of a reactive mesogen in a small molecular chiral liquid crystal (CLC), polymerization, and removal of the CLC. The prepolymer of polyurethane acrylate (PUA) is then infiltrated in the prepared scaffold and subsequently photo-polymerized to form a CLC-PUA composite film.

Real-World Safety and Clinical Outcomes of Macitentan in Asian Patients with Pulmonary Arterial Hypertension: A Prospective Multicenter Study.

Background And Objective: Macitentan is approved for treating pulmonary arterial hypertension. However, the real-world evidence of macitentan use is limited. Therefore, we evaluated the safety and clinical outcomes of macitentan use in clinical practice under a post-marketing surveillance.

Method for spot urine normalization by K in a radiation emergency.

In this study, to assess the internal radiation dose in radiation emergencies, the variability of spot urine normalization methods is studied using K measurement results. The mean creatinine concentration and the mean K activity concentration in the spot urine samples studied were 139 mg dL and 106 Bq kg, respectively. The results indicate that the K activity concentration method can be used to complement the method used for normalizing the creatinine concentration in spot urine in a radiological emergency.

Improving the resilience of SMEs in times of crisis: The impact of mobile money amid Covid-19 in Zambia.

This study investigates the impact of mobile money (MM) on SMEs' resilience and the associated business outcome in developing countries amid Covid-19. Despite the potential of MM to improve SMEs' resilience, little evidence has been documented. Using Enterprise Survey data in Zambia, we show that SMEs are more likely than large firms to experience catastrophic sales decline, reflecting their inherent vulnerability.

GALNT3 suppresses lung cancer by inhibiting myeloid-derived suppressor cell infiltration and angiogenesis in a TNFR and c-MET pathway-dependent manner.

The deregulation of polypeptide N-acetyl-galactosaminyltransferases (GALNTs) contributes to several cancers, but their roles in lung cancer remain unclear. In this study, we have identified a tumor-suppressing role of GALNT3 in lung cancer. We found that GALNT3 suppressed lung cancer development and progression in both xenograft and syngeneic mouse models.

Sorption of anthracene (CH) and 9-anthroic acid (CHO) onto biochar-amended soils as affected by field aging treatments.

There is a lack of information on how aging affects the sorption of ionizable organic compounds on biochar-amended soils. To that end, this study investigates the sorption of two hydrophobic solutes (anthracene (ANT) and 9-anthroic acid (9-ANCA)) onto biochar-amended (5%, w/w) soils as a function of aging period (0, 6, and 12 months), electrolyte (5 mM CaCl and 10 mM KCl), and aqueous pH. The isotherm plot of both solutes was fairly linear (r > 0.

PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment.

Poly (ADP-ribose) polymerase 1 (PARP1) and polycomb-repressive complex 2 (PRC2) are each known for their individual roles in cancer, but their cooperative roles have only been studied in the DNA damage repair process in the context of BRCA-mutant cancers. Here, we show that simultaneous inhibition of PARP1 and PRC2 in the MDA-MB-231 BRCA-proficient triple-negative breast cancer (TNBC) cell line leads to a synthetic viability independent of the mechanisms of DNA damage repair. Specifically, we find that either genetic depletion or pharmacological inhibition of both PARP1 and PRC2 can accelerate tumor growth rate.

Validation of the whole-body counting measurement in a radiation emergency.

Whole-body measurement can provide fast and accurate results in radiation emergencies. The whole-body counting method needs to be validated to guarantee the reliability and accuracy of the measurement. This study provides data related to the validation of the whole-body measurement using the stand-up type whole-body counter.

Effect of HNO and HSO on the Paddy Ecosystem: A Mesocosm Study with Exposure at PNEC and HC Levels.

Paddy mesocosms comprising of rice (), snail (), and worm () were used to assess the damage caused by two acids (HNO and HSO) at predicted no-effect concentration (PNEC) and hazardous concentration for 50% of species (HC) levels. In the fourth week, the fresh weight and shoot height of at HSO-HC were reduced by 83.2% and 30.

PRACTICAL METHODS FOR INTERNAL DOSE ASSESSMENT FOR RADIOIODINE INTAKE AFTER THYROID BLOCKING: CLASSIFICATION OF DEGREE OF BLOCKAGE AND DETERMINATION OF INSENSITIVE MEASUREMENT POINT.

Iodine thyroid blocking (ITB) suppresses the uptake of iodine to the thyroid and reduces internal doses after radioiodine intake; however, its disturbance of thyroid biokinetics causes considerable uncertainty in the use of dosimetric data intended for assessment of unblocked normal thyroid. To more accurately assess internal dose after ITB, practical dosimetry methods were proposed that consider the ITB effect in a dosimetric manner. A method using the ratio of urine excretion to thyroid retention activity was proposed to retrospectively determine individual-specific ITB levels; bioassay functions and dose coefficients corresponding to ITB levels were calculated separately using the latest biokinetic model and fundamental data.

Internal Dose Assessment after 131I-Iodide Misadministration in a Patient With Incompletely Blocked Thyroid Uptake: Personalized Internal Dose Assessment by Estimating Individual-Specific Biokinetics.

In July 2017, a medical accident occurred in South Korea, in which I-iodide solution was misadministered to the wrong patient. Although the International Commission on Radiological Protection provided internal dose coefficients for iodine for blocked thyroid, they were not reliable enough for determining the dose to the patient (whose thyroid uptake was incompletely blocked) due to a discrepancy in biokinetics. Therefore, a personalized dose assessment was performed to derive the individual-specific dose coefficients for the patient.

Counting Efficiencies Determined by Monte Carlo Methods for In Vivo Measurement of 131I Activity in Thyroid.

The counting efficiencies obtained using a physical neck phantom are typically used in the measurement of I activity in the thyroid. It is well known, however, that the geometrical discrepancies between the physical neck phantom and the anatomy of the subject can significantly influence the counting efficiencies. Thus, it is necessary to consider the anatomical characteristics of individuals if we need to accurately determine the activity of I in the thyroid.

Role of non-electrostatic forces in antimicrobial potency of a dengue-virus derived fusion peptide VG16KRKP: Mechanistic insight into the interfacial peptide-lipid interactions.

Cationic antimicrobial peptides (AMPs) are emerging as effective alternatives to conventional therapeutics that are used against the ever-rising number of multidrug-resistant microbial strains. Most studies established the peptide's amphipathicity and electrostatic interaction with the membrane as the basis for their antimicrobial effect. However, the interplay between the stoichiometric ratio of lipids, local geometry, diverse physicochemical properties of the host membranes and antimicrobial peptide efficacy is still poorly understood.

Measurement and Simulation of the Counting Efficiency of a Whole-body Counter Using a BOMAB Phantom Inserted with Rod Sources Containing Mixed Radionuclides.

The examination of internal contamination is important for providing an adequate medical response during a radiological emergency. A whole-body counting system can assess gamma-emitting radionuclides in a human body when monitoring internal contamination. It is necessary to calibrate whole-body counting systems by using a calibration phantom, such as a Bottle Manikin Absorption phantom, to properly assess internal contamination.

Caregiver Preference and Treatment Compliance in Patients with Mild-to-Moderate Alzheimer's Disease in South Korea: RECAP Study Results.

Introduction: The aim of this study was to assess caregiver preference and treatment compliance with oral and transdermal medications in a "real-world" setting in patients with mild-to-moderate Alzheimer's disease (AD) in South Korea.

Methods: Real-world evaluation of compliance and preference in Alzheimer's disease treatment (RECAP) was a 24-week, multicenter, prospective, non-interventional study in patients with AD treated with oral or transdermal therapy. Here, we report data from patients living in South Korea.

Monte Carlo simulation-based feasibility study of novel indirect flat panel detector system for removing scatter radiation.

The purpose of this study is to investigate the feasibility of a novel indirect flat panel detector (FPD) system for removing scatter radiation. The substrate layer of our FPD system has a Pb net-like structure that matches the ineffective area and blocks the scatter radiation such that only primary X-rays reach the effective area on a thin-film transistor. To evaluate the performance of the proposed system, we used Monte Carlo simulations to derive the scatter fraction and contrast.

Hexane extract from Sargassum serratifolium inhibits the cell proliferation and metastatic ability of human glioblastoma U87MG cells.

The present study is the first to demonstrate the anticancer effects of a hexane extract from the brown algae Sargassum serratifolium (HES) on human cancer cell lines, including glioblastoma U87MG, cervical cancer HeLa and gastric cancer MKN-28 cells, as well as liver cancer SK-HEP 1 cells. Among these cancer cell lines, U87MG cells were most sensitive to the cell death induced by HES. HES exhibited a cytotoxic effect on U87MG cells at concentrations of 14-16 µg/ml, yet an effect was not observed in human embryonic kidney HEK293 cells.

Antimetastatic effects of gambogic acid are mediated via the actin cytoskeleton and NF-κB pathways in SK-HEP1 cells.

Hepatocellular carcinoma (HCC) is one of the most malignant and frequent cancers with a high metastatic potential. The prevention of HCC metastasis is a critical target for effective therapies in HCC. Gambogic acid (GA), a natural compound obtained from Garcinia hanburyi has reported anticancer activity in cell lines.

Monte Carlo simulation-based feasibility study of a dose-area product meter built into a collimator for diagnostic X-ray.

According to the International Electro-technical Commission, manufacturers of X-ray equipment should indicate the number of radiation doses to which a patient can be exposed. Dose-area product (DAP) meters are readily available devices that provide dose indices. Collimators are the most commonly employed radiation beam restrictors in X-ray equipment.

Trends of the effective dose distribution of occupational exposures in medical and research departments for KIRAMS in Republic of Korea.

This work proposes the basic reference data of occupational dose management and statistical dose distribution with the classification of radiation work groups though analysis of occupational dose distribution. Data on occupational radiation exposure from medical and scientific usage of radiation in Korea Institute of Radiological and Medical Sciences for the years 2002-11 are presented and evaluated with the characteristic tendency of radiation working groups. The results of occupational radiation exposure were measured by personal dosemeters.

Estimation of absorbed organ doses and effective dose based on body mass index in digital radiography.

With the introduction of digital radiography, patients undergoing radiographic procedures are subject to being overexposed to radiation. Therefore, it is necessary to estimate the absorbed organ dose and the effective dose, which are significant for patient health, along with body type. During chest radiographic examinations conducted in 899 patients for screening, the absorbed dose of the 13 major organs, the average whole-body dose, and two effective doses weighted by factors published in ICRP 60 and ICRP 103 were calculated on the basis of patient information such as height, weight and examination condition, including kilovolt potential, focus-skin distance and entrance surface dose (ESD), using a PC-based Monte Carlo program simulation.

Vehicle Signal Analysis Using Artificial Neural Networks for a Bridge Weigh-in-Motion System.

This paper describes the procedures for development of signal analysis algorithms using artificial neural networks for Bridge Weigh-in-Motion (B-WIM) systems. Through the analysis procedure, the extraction of information concerning heavy traffic vehicles such as weight, speed, and number of axles from the time domain strain data of the B-WIM system was attempted. As one of the several possible pattern recognition techniques, an Artificial Neural Network (ANN) was employed since it could effectively include dynamic effects and bridge-vehicle interactions.

Application of a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with orthogonal projections to latent structure-discriminant analysis as an efficient tool for discriminating between Korean and Chinese herbal medicines.

Correct identification of the origins of herbal medical products is becoming increasingly important in tandem with the growing interest in alternative medicine. However, visual inspection of raw material is still the most widely used method, and newer scientific approaches are needed. To develop a more objective and efficient tool for discriminating herbal origins, particularly Korean and Chinese, we employed a nuclear magnetic resonance (NMR)-based metabolomics approach combined with an orthogonal projections to latent structure-discriminant analysis (OPLS-DA) multivariate analysis.