Publications by authors named "Minouk Lee"
Genome-scale metabolic modeling and analysis of opportunistic skin pathogen .
Front Cell Infect Microbiol
August 2023
Article Synopsis
- One of the most abundant skin microbes, linked to acne development, becomes problematic when its strains are imbalanced, highlighting the need for targeted treatment strategies.
- Researchers created a genome-scale metabolic model (GEM) for the virulent strain CA843 to better understand its behavior in skin environments and validated its predictions against experimental data.
- They identified specific biosynthetic pathways in the model related to short-chain fatty acids, discovered the Wood-Werkman cycle's role in propionate production, and suggested potential anti-acne targets using a systematic, model-based approach.