A pilot study of combination therapy with initial high-dose interferon and amantadine hydrochloride for patients with chronic hepatitis C with the genotype 1b virus.

Background/aims: Interferon monotherapy for patients with chronic hepatitis C has been suboptimal. We studied the effect of the combination therapy of an initial high-dose of interferon and amantadine.

Methodology: We investigated the virological response of 20 patients with naive chronic hepatitis C with a high viral load of the genotype 1b virus.

The combination therapy of interferon and amantadine hydrochloride for patients with chronic hepatitis C.

Background/aims: The effect of interferon treatment for chronic hepatitis C patients with genotype 1b virus has been suboptimal. We studied the effect of the combination therapy of interferon and amantadine on patients with a high serum viral load of genotype 1b virus.

Methodology: We studied the virological response of naive chronic hepatitis C patients with a high viral load of genotype 1b virus (4.