Publications by authors named "Minoru Kato"

Background: Patients with esophageal squamous cell carcinoma (ESCC) frequently develop synchronous head and neck squamous cell carcinoma (HNSCC). With advances in endoscopic technology and widespread screening of synchronous cancers, the detection of synchronous HNSCC and superficial ESCC (SESCC) is increasing. We aimed to evaluate the impact of preceding HNSCC treatment on synchronous SESCC.

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  • * Key factors linked to bleeding included the use of antithrombotic agents, the size of the resection wound, and specimen size.
  • * Direct oral anticoagulants (DOACs) were significantly associated with higher bleeding rates, indicating a need for caution in patients on these medications during postoperative recovery.
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  • This study looked at women with bladder cancer who had surgery to remove their bladder and other reproductive organs to see how many still had problems with their reproductive organs.
  • Out of 417 women, some had their uterus and vaginal wall saved, but about 9% showed signs of cancer in their reproductive areas.
  • The researchers concluded that doctors need to think carefully about whether to save these organs during surgery because there's a risk that cancer could still affect them.
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  • Privalov and colleagues studied how hydration enthalpy and entropy change when the protein ubiquitin unfolds, using measurements from various model compounds transitioning from gas to water.
  • They applied statistical-mechanics theory with molecular and atomistic models to estimate these changes, finding their results align well with Privalov's estimates.
  • The study emphasizes the importance of the hydrophobic effect in protein folding and presents new insights into understanding its weakening at lower temperatures, while also addressing issues with measuring changes in enthalpy and entropy at low pH and proposing methods for calculations at neutral pH.
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  • - This study aimed to create a prognostic model to estimate the risk of cancer-specific mortality in bladder cancer patients after radical cystectomy (RC), using data from 36 institutions in Japan.
  • - Researchers analyzed patient data without adjuvant chemotherapy, splitting it into training and validation sets, and used a multivariable Cox regression model to predict outcomes based on 25 variables.
  • - The final model, which included eight key variables, outperformed the existing CheckMate 274 classification, correctly reclassifying a significant portion of high-risk patients into a better prognosis group, enhancing potential treatment decisions.
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  • This study investigated the effectiveness and safety of endoscopic resection for lesions in patients with head and neck squamous cell carcinoma that developed after radiation therapy.
  • A total of 43 patients with 57 lesions underwent this procedure, achieving complete resection in all cases, with manageable adverse events occurring in a minority of patients.
  • The results showed good long-term outcomes, with low rates of local recurrence and high survival rates, indicating that endoscopic dissection is a safe and effective option for these patients.
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A 74-year-old man visited the urology clinic with the chief complaint of urinary retention in December 2014. Serum level of initial prostate specific antigen (PSA) was 50 ng/ml and he was diagnosed with Gleason Score 4+4 prostate adenocarcinoma with regional lymphadenopathy (cT3aN1M0). PSA level had declined after the treatment with combined androgen blockade.

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Introduction: Urinary fistula is a rare complication following robot-assisted partial nephrectomy. For cases refractory to conservative treatment, only ureteral stent placement and percutaneous drainage are the established treatment alternatives.

Case Presentation: A 44-year-old man presented with urinary fistula 3 weeks after robot-assisted partial nephrectomy for right renal cell carcinoma.

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Background And Aims: There is a high incidence of stricture after endoscopic submucosal dissection (ESD) for cervical esophageal cancer. We aimed to elucidate the risk factors for stricture and to evaluate the efficacy of steroid injection for stricture prevention in the cervical esophagus.

Methods: We retrospectively analyzed 100 patients who underwent ESD for cervical esophageal cancer to (1) identify the factors associated with stricture among patients who did not receive steroid injection, and (2) compare the incidence of stricture between patients with and without steroid injection.

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Objectives: To determine the effects of prophylactic urethrectomy (PU) on oncological and perioperative outcomes in patients with bladder cancer (BC) undergoing radical cystectomy (RC).

Methods: This retrospective study analyzed data on 1976 evaluable patients with BC who underwent RC. Patients were drawn from 36 institutions within the Japanese Urological Oncology Group.

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Background: We developed a machine learning (ML) model to predict the risk of lymph node metastasis (LNM) in patients with early gastric cancer (EGC) who did not meet the existing Japanese endoscopic curability criteria and compared its performance with that of the most common clinical risk scoring system, the eCura system.

Methods: We used data from 4,042 consecutive patients with EGC from 21 institutions who underwent endoscopic submucosal dissection (ESD) and/or surgery between 2010 and 2021. All resected EGCs were histologically confirmed not to satisfy the current Japanese endoscopic curability criteria.

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  • Researchers developed an AI endoscopic ultrasonography (EUS) system to accurately assess the invasion depth of early gastric cancer (EGC) using a large dataset of EUS images.
  • The system was trained and validated using images from 11 institutions, demonstrating a strong performance with an area under the curve (AUC) of 0.870 in internal validation and 0.815 in external validation.
  • The AI's diagnostic accuracy was comparable to that of both expert and non-expert human evaluators, indicating its potential for reliable use in clinical settings.
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: Our aim was to clarify the oncological outcomes of the two different approaches to laparoscopic nephroureterectomies (LNUs) in Japan, and to examine whether there were any significant differences between the transperitoneal approach and the retroperitoneal approach. : We retrospectively evaluated patients who underwent an LNU for upper tract urothelial carcinoma (UTUC) from January 2013 to December 2022. We identified 52 patients who underwent a transperitoneal LNU (tLNU) and 93 who underwent a retroperitoneal LNU (rLNU).

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Objectives: The high rate of delayed bleeding after colorectal endoscopic submucosal dissection (ESD) in patients undergoing anticoagulant therapy remains a problem. Whether prophylactic clip closure reduces the rate of delayed bleeding in these patients is unclear. This study aimed to evaluate the efficacy of prophylactic clip closure in patients receiving anticoagulants.

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Objective: To analyse the impact of histological discordance of subtypes (subtypes or divergent differentiation [DD]) in specimens from transurethral resection (TUR) and radical cystectomy (RC) on the outcome of the patients with bladder cancer receiving RC.

Patients And Methods: We analysed data for 2570 patients from a Japanese nationwide cohort with bladder cancer treated with RC between January 2013 and December 2019 at 36 institutions. The non-urinary tract recurrence-free survival (NUTR-FS) and overall survival (OS) stratified by TUR or RC specimen histology were determined.

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Objectives: Immune checkpoint inhibitors and enfortumab vedotin have opened new avenues for sequential treatment strategies for locally advanced/metastatic urothelial carcinoma (la/mUC). In the pre-enfortumab vedotin era, many patients could not receive third-line treatment owing to rapid disease progression and poor general status. This study aimed to analyze real-world sequential treatment practices for la/mUC in Japan, with a focus on patients who do not receive third-line treatment.

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  • A 72-year-old man had a large adrenal tumor discovered via CT scan, but tests showed normal hormone levels and no signs of adrenal hyperfunction.
  • Further imaging revealed thickening in the sigmoid colon, leading to a colonoscopy that identified a tumor, which was diagnosed as intermediate differentiated ductal adenocarcinoma.
  • Surgical intervention involved removing the sigmoid colon and the left adrenal gland, confirming that the adrenal tumor was a metastasis from the colorectal cancer.
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A 66-year-old man presenting with cStage Ⅲc rectal cancer underwent laparoscopic low anterior resection(D3 lymph node dissection and R0 resection)following neoadjuvant chemoradiotherapy(capecitabine, 45 Gy/25 Fr)and received adjuvant chemotherapy(CAPOX). A year after surgery, abdominal contrast-enhanced computed tomography revealed recurrence near the rectal anastomosis with prostate invasion. The patient underwent robot-assisted abdominoperineal resection alongside en bloc prostatectomy and vesico-urethral anastomosis after 12 courses of neoadjuvant chemotherapy(FOLFIRI and panitumumab).

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An unmet needs survey was conducted among cancer patients, their families, and others affected by cancer during the 10-year period from 2011 to 2022 to clarify the actual situation regarding access to information, treatment choices, daily quality of life, and psychosocial support from the perspective of cancer patients, and to explore characteristics, problems, and issues in the categories of common cancers, rare cancers, and pediatric cancers. The desire for successful treatment itself is the same regardless of the type of cancer. However, economic and psychological burdens are closely related to age and life stage, and second opinions and necessary information differ by cancer type.

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The use of left ventricular assist device (LVAD) implantation has increased in recent years. Here, we report the first case of gastric endoscopic submucosal dissection (ESD) following LVAD implantation. A 69-year-old man who previously underwent LVAD implantation for severe heart failure underwent esophagogastroduodenoscopy, which revealed a 15-mm flat-elevated cancerous lesion at the greater curvature of the gastric angle.

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Introduction: We aimed to evaluate the natural course of sporadic nonampullary duodenal adenomas (SNDAs) and determine the risk factors of progression.

Methods: We retrospectively analyzed the follow-up outcomes of patients with biopsy-diagnosed SNDA between April 2010 and March 2016 at 13 institutions. All initial biopsy specimens were centrally evaluated.

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  • * Methods: Researchers analyzed the clinical data of 409 patients who had undergone surgeries for bladder and upper tract urothelial cancers, examining factors like chemotherapy and lymph node dissection impacts on recurrence risk.
  • * Results: High-risk patients had significantly shorter disease-free survival than low-risk ones, with a low usage of adjuvant chemotherapy; the study confirmed that being classified as high-risk based on CheckMate 274 is a poor prognostic indicator for both types of cancer
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  • * This study aimed to identify specific DNA methylation changes in rat bladder cancer caused by dimethylarsinic acid (DMA), finding 40 genes that were both hypermethylated and downregulated in these tumors.
  • * Key genes identified (CPXM1, OPCML, TBX20, and KCND3) showed reduced expression after DMA exposure and are also affected in human bladder cancers, suggesting these changes occur early in arsenic-induced cancer development and may be potential therapeutic targets.
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