Tumor Suppression by Anti-Fibroblast Activation Protein Near-Infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts.

Cancer-associated fibroblasts (CAFs) constitute a prominent cellular component of the tumor stroma, with various pro-tumorigenic roles. Numerous attempts to target fibroblast activation protein (FAP), a highly expressed marker in immunosuppressive CAFs, have failed to demonstrate anti-tumor efficacy in human clinical trials. Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor therapy that utilizes an antibody-photo-absorbing conjugate activated by near-infrared light.

Prenatal exposure to ambient air pollutants and early infant growth and adiposity in the Southern California Mother's Milk Study.

Background: Prior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors in childhood and adolescence. However, few studies have assessed changes in infant body composition or multiple pollutant exposures. Therefore, the objective of this study was to examine relationships between prenatal residential AAP exposure with infant growth and adiposity.

Decrease in Ambient Polycyclic Aromatic Hydrocarbon Concentrations in California's San Joaquin Valley 2000-2019.

As part of our ongoing research to understand the impact of polycyclic aromatic hydrocarbon (PAH) exposures on health in the San Joaquin Valley, we evaluated airborne PAH concentration data collected over 19 years (2000-2019) at the central air monitoring site in Fresno, California. We found a dramatic decline in outdoor airborne PAH concentrations between 2000 and 2004 that has been maintained through 2019. This decline was present in both the continuous particle-bound PAHs and the filter-based individual PAHs.

Review of Sunset OC/EC Instrument Measurements During the EPA's Sunset Carbon Evaluation Project.

To evaluate the feasibility of the Sunset semicontinuous organic and elemental carbon (OC/EC) monitor, the U.S. Environmental Protection Agency (EPA) sponsored the deployment of this monitor at Chemical Speciation Network (CSN) sites with OC and EC measurements via quartz fiber filter collection in Chicago, Illinois; Houston, Texas; Las Vegas, Nevada; St.

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures.

Background: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited.

Objectives: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery.

Methods: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA ) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB).

Evaluation of a Mindfulness-Based Stress Reduction (MBSR) program for caregivers of children with chronic conditions.

Objectives: Given the demands of caring for chronically ill children, it is not surprising that caregivers often experience high levels of chronic stress. A Mindfulness-Based Stress Reduction (MBSR) program may offer relief to these caregivers by providing tools for self-care and heath promotion that otherwise may be lacking.

Methods: MBSR classes were offered without restriction to parents of children attending various clinics at a large urban children's medical centre.

A chemical basis for differential allelopathic potential of sorghum hybrids on wheat.

The basis for differential allelopathic potentials among sorghum (Sorghum bicolor L. Moench) hybrids was investigated by conducting quantitative and qualitative studies of their phenolic contents. Total phenolic content in sorghum plant parts varied within hybrids, among hybrids, and between growing seasons.

A rapid, sensitive thin layer chromatography procedure for the detection of fumonisin B1 and B2.

A thin layer chromatography (TLC) method was developed for the detection of fumonisin B1 and B2 in corn and corn-based feedstuffs. Finely ground samples were extracted with acetonitrile:water (1:1), filtered, and applied to C18 cleanup columns. The columns were washed with 1% aqueous KCl followed by acetonitrile: 1% aqueous KCl (1:9), and the fumonisins were eluted with acetonitrile:water (7:3).

Response of Soybean Cultivars to Aldicarb in Heterodera glycines-infested Soils in Missouri.

Soybean cultivars in maturity groups III, IV, and V that were resistant or susceptible to Heterodera glycines were evaluated for their response to in-furrow applications (5.43 kg a.i.

Stem infusions enhanced methionine content of soybean storage protein.

The quality of soybean (Glycine max [L.] Merrill) seed storage protein is limited by its low methionine (Met) content. Met supplementation of an in vitro soybean cotyledon culture has been shown to increase Met content by 21.

P Nutrition during Seed Development : Leaf Senescence, Pod Retention, and Seed Weight of Soybean.

Soybean (Glycine max [L.] Merrill) leaf senescence, which may partially result from mineral redistribution, appears to limit grain yield. Two experiments were designed to test the effects of supplemental inorganic phosphate (Pi), K, malate, and methionine (Met) infusions on senescence and yield.

Germination Effects on Flatus-Causing Factors and Antinutrients of Mungbeans and Two Strains of Small-Seeded Soybeans.

Two strains of small-seeded soybeans contained greater amounts of stachyose and raffinose than market samples of mungbean seeds. These sugars either disappeared or were reduced to trace amounts during 3 d of germination for mungbeans and 4 d for soybeans. Both soybean strains contained more phytic acid and trypsin inhibitor than mungbeans.