Publications by authors named "Minna Manninen"

Background: Mutualistic mycorrhiza fungi that live in symbiosis with plants facilitates nutrient and water acquisition, improving tree growth and performance. In this study, we evaluated the potential of mutualistic fungal inoculation to improve the growth and disease resistance of Scots pine (Pinus sylvestris L.) against the forest pathogen Heterobasidion annosum.

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Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data.

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A multicenter study was set up to elucidate the environmental and medical risk factors contributing to age-related hearing impairment (ARHI). Nine subsamples, collected by nine audiological centers across Europe, added up to a total of 4,083 subjects between 53 and 67 years. Audiometric data (pure-tone average [PTA]) were collected and the participants filled out a questionnaire on environmental risk factors and medical history.

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Article Synopsis
  • Age-related hearing impairment (ARHI) is a common condition in the elderly, influenced by both environmental and genetic factors.
  • A study involving 2,418 ARHI samples from Europe focused on 70 candidate genes, identifying a significant association with a single nucleotide polymorphism (SNP) in the GRHL2 gene.
  • Analysis showed consistent results across multiple centers, suggesting that the associated SNPs may impact the expression of a GRHL2 isoform and contribute to ARHI.
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