Publications by authors named "Minna Malmstedt"
Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor (TKI) sensitivity have been reported in PM-ccRCC. However, no functional or single-cell studies have been conducted thus far.
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- Immunotherapy, particularly using oncolytic adenoviruses that express specific cytokines, shows potential for treating clear cell renal cell carcinoma (ccRCC).
- The study found that adenovirus treatment led to increased cytokine secretion and significant T-cell migration toward treated tumor cells, highlighting the role of CXCR3 receptors on T-cells, especially CD8+ T-cells.
- Additionally, the research identifies immunogenic antigens that could improve the effectiveness of adenoviral treatments and emphasizes the importance of patient-derived organoids for developing and validating new immunotherapy strategies.
Dendritic cell (DC)-based vaccines have shown some degree of success for the treatment of prostate cancer (PC). However, the highly immunosuppressive tumor microenvironment leads to DC dysfunction, which has limited the effectiveness of these vaccines. We hypothesized that use of a fully serotype 3 oncolytic adenovirus (Ad3-hTERT-CMV-hCD40L; TILT-234) could stimulate DCs in the prostate tumor microenvironment by expressing CD40L.
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