Chinese version of the Perth Alexithymia Questionnaire: psychometric properties and clinical applications.

Background: The alexithymia trait is of high clinical interest. The Perth Alexithymia Questionnaire (PAQ) was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia.

Aims: In this paper, we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical applications.

The combination of accent method and phonemic contrast: an innovative strategy to improve speech production on post-stroke dysarthria.

Introduction: Speech production includes segmental and suprasegmental features, which interact and cooperate with each other. Impaired speech production is common in individuals with post-stroke dysarthria. The commonly used phonemic contrast therapy and Accent Method in clinical practice can improve the segmental and suprasegmental aspects, respectively.

Quantitative acoustic metrics of vowel production in mandarin-speakers with post-stroke spastic dysarthria.

Impairment of vowel production in dysarthria has been highly valued. This study aimed to explore the vowel production of Mandarin-speakers with post-stroke spastic dysarthria in connected speech and to explore the influence of gender and tone on the vowel production. Multiple vowel acoustic metrics, including F1 range, F2 range, vowel space area (VSA), vowel articulation index (VAI) and formant centralization ratio (FCR), were analyzed from vowel tokens embedded in connected speech produced.

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits.

Background: To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI).

Methods: A total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients.

A preliminary study of 3.0-T magnetic resonance diffusion tensor imaging in cervical spondylotic myelopathy.

Purpose: To compare diffusion tensor imaging (DTI) parameters of the spinal cord between patients with cervical spondylotic myelopathy (CSM) and normal subjects, and investigate their significance in the clinical diagnosis, surgical planning and post-operative evaluation of CSM.

Methods: Routine sequence magnetic resonance imaging (MRI) and DTI scans were performed in 50 normal subjects and 60 cases of CSM with 3.0-T MR.

Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease.

Background And Objectives: Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was to investigate the correlations between cognition and function changes of the DMN in COPD patients.

Highly enantioselective zinc/amino alcohol-catalyzed alkynylation of aldehydes.

Meeting the challenge: The zinc/amino alcohol catalyzed enantioselective addition of terminal alkynes to aldehydes is effective with both phenylacetylene and methyl propiolate, leading to chiral secondary propargyl alcohols with very high enantioselectivity (see scheme).