Publications by authors named "Minling Yu"
Background: The pathogenesis of multiple sclerosis (MS) may be closely related to immune regulation and inflammatory cytokines induced by specific flora. Repairing the intestinal flora may alter the immune response in MS patients, thus opening up novel approaches for the treatment of MS.
Objective: We aimed to test the therapeutic effect of fecal microbiota transplantation (FMT) on experimental autoimmune encephalomyelitis (EAE) and the characteristics of intestinal microbiota composition changes, explore the potential mechanisms of FMT treatment.
Objective: To analyze the initial symptom and the cause of the misdiagnosis of Wilson's Disease (WD) so as to enhance awareness of this condition and reduce diagnostic errors.
Methods: The clinical data of 179 patients with the confirmed diagnosis of WD who were hospitalized in the First Affiliated Hospital of Guangdong Pharmaceutical University from October 2014 to September 2021 were analyzed. Those patients who had attended two or more hospitals, had been misdiagnosed as other diseases, or failed to get a clear diagnosis for 3 months and over before hospitalization were included in the group of clinical misdiagnosis or the group without a definite diagnosis.
Article Synopsis
- Researchers aim to observe atomic motions in chemical reactions in real time and have used X-ray free-electron lasers (XFELs) for this purpose, but few natural photoactive proteins have been studied due to limited phototriggers.
- A new method involves genetically encoding a xanthone amino acid (FXO) into a modified human liver fatty-acid binding protein (XOM), enabling efficient photo-induced C-H bond transformations.
- The study successfully captured excited-state intermediates of XOM before and after illumination, suggesting that this technique can now be applied to other redox enzymes to better understand their reaction mechanisms.
Article Synopsis
- * A new fluorescent sensor has been created by incorporating a synthetic amino acid into fatty acid-binding proteins, allowing for a noticeable increase in signal when fatty acids are present.
- * This detection system enhances research capabilities in studying fatty acids and their roles in biological processes through advanced molecular technology.
Human indoleamine 2,3-dioxygenase 1 (IDO1) has become an increasingly valuable target for cancer immunotherapy because it promotes immune escape by tumor cells. To date, the function of post-translational modifications (PTMs) on IDO1 has not been fully elucidated. Among the many forms of PTMs, it has been identified that three tyrosine sites (Y15, Y345, and Y353) on IDO1 are nitrated and play important roles in catalytic function.
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