CD40L-Activated DC Promotes Th17 Differentiation and Inhibits Th2 Differentiation in Sepsis-Induced Lung Injury via cGAS-STING Signaling.

Immune hemostasis due to an infection plays a vital role in sepsis-induced multiple organ dysfunction. Dendritic cells (DC) and T helper (Th) cells are the key members of the immune system maintaining immune homeostasis. This study aimed to explore the effect and mechanism of CD40L on the activation of DC and activated DC-induced Th2/Th17 differentiation.

C-reactive protein to albumin ratio as a prognostic tool for predicting intravenous immunoglobulin resistance in children with kawasaki disease: a systematic review of cohort studies.

Background: Intravenous immunoglobulin (IVIG) is the primary treatment for Kawasaki disease (KD). However, 10-20% of KD patients show no response to IVIG treatment, making the early prediction of IVIG resistance a key focus of KD research. Our aim is to explore the application of the C-reactive protein to albumin ratio (CAR) for predicting IVIG resistance in children with KD through meta-analysis.

Body mass index changes after transjugular intrahepatic portosystemic shunt in individuals with cirrhosis.

Objectives: Liver cirrhosis is often accompanied by portal hypertension and malnutrition, two common complications that seriously affect treatment efficacy and quality of life. This study aimed to investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on body mass index (BMI) and metabolism in individuals with cirrhotic portal hypertension, and the risk factors that affect changes of BMI.

Methods: A retrospective study was performed to collect basic information before and after TIPS.

Development and evaluation of a rapid CRISPR-based diagnostic for COVID-19.

The recent outbreak of human infections caused by SARS-CoV-2, the third zoonotic coronavirus has raised great public health concern globally. Rapid and accurate diagnosis of this novel pathogen posts great challenges not only clinically but also technologically. Metagenomic next-generation sequencing (mNGS) and reverse-transcription PCR (RT-PCR) have been the most commonly used molecular methodologies.

Heterostructured BiOCO/rGO/PDA photocatalysts with superior activity for organic pollutant degradation: Structural characterization, reaction mechanism and economic assessment.

Compared with conventional methods for organic pollutant degradation, photocatalysis is a promising treatment technology with broad application prospects. BiOCO is often used for organic pollutants degradation but greatly restricted by having drawbacks of large band gap and high electron-hole recombination rate. Herein, heterostructured BiOCO (BOC)/reduced graphene oxide (rGO)/polydopamine (PDA) (BGP) photocatalysts were first designed through a green chemical method.

CRISPR-based rapid and ultra-sensitive diagnostic test for .

Rapid and simple-to-use diagnostic methods for tuberculosis are urgently needed. Recent development has unveiled the diagnostic power of the CRISPR system in the detection of viral infections. However, its potential use in detecting the complex (MTB) remained unexplored.

Impacts of Related Risk Factors on the Efficacy of Interventional Treatment Towards Intractable Postpartum Hemorrhage.

Objective: To investigate the risk factors that impact the efficacy of interventional treatment of intractable postpartum hemorrhage (IPH).

Study Design: A total of 64 IPH patients were admitted and received interventional treatment at First Hospital of Shanxi Medical University from January 2012 to September 2014, among whom 57 cases were successfully treated (bleeding stopped), while 7 cases failed. The clinical data of the success group and the failure group were observed for the multivariate analysis of the possible reasons that might cause hemostatic failure.

Clinical efficacy of percutaneous transluminal renal artery stenting for the treatment of renovascular hypertension associated with Takayasu arteritis.

Background: This study aims to observe and analyze the clinical efficacy of interventional therapy for patients with Takayasu arteritis (TA) experiencing renovascular hypertension (RH).

Methods: Eight TA patients with RH underwent percutaneous transluminal renal artery stenting (PTRAS). Patients were followed up 1, 6, 12, and 24 months postoperatively for levels of blood pressure, number of antihypertensive drugs being taken, levels of serum creatinine, and the presence of renal artery restenosis.