Publications by authors named "Minkyue Shin"
Article Synopsis
- Advances in chemotherapy and immunotherapy have allowed some stage IV gastric cancer patients to undergo conversion surgery after significant tumor regression from palliative chemotherapy.
- A study involving 118 patients at Samsung Medical Center evaluated various baseline and post-chemotherapy features, finding that 21 patients achieved a complete pathologic response and 97 patients were downstaged.
- Important factors for prognostic evaluation included BMI, HER2 status, and other molecular markers, suggesting that conversion surgery can be an option for more patients regardless of their initial disease severity.
Article Synopsis
- Programmed death-ligand 1 (PD-L1) is a key biomarker for selecting gastric cancer patients for immune checkpoint inhibitor (ICI) treatments, and this study reviewed the PD-L1 status of 399 patients from 2019 to 2021.
- The results showed that 69% of patients had a PD-L1 combined positive score (CPS) ≥1, with a CPS ≥5 indicating better survival rates and higher objective response rates to ICI therapy.
- The study concluded that PD-L1 expression serves as an important biomarker for ICI efficacy, and combining ICI with targeted therapies might enhance treatment strategies for gastric cancer.
Article Synopsis
- The study identifies specific gene signature-based subtypes of gastric cancer (GC) that are linked to treatment resistance and poor outcomes, analyzing data from 547 cases.
- Researchers explored the relationship between these cancer subtypes and the tumor microenvironment using advanced techniques, revealing that some GC cells are in a partial epithelial-mesenchymal transition state.
- By targeting TGF-β signaling, which they found to drive mesenchymal traits in cancer cells, the study suggests new therapeutic strategies that could reduce resistance to treatment in gastric cancer.
Article Synopsis
- The study introduces CanICU, a new machine learning model designed to predict 28-day mortality in critically ill cancer patients admitted to ICUs, based on data from multiple medical centers.
- The model incorporates nine clinical and laboratory factors using a random forest algorithm, achieving a high sensitivity of 96% and specificity of 73%, outperforming existing models like APACHE and SOFA.
- CanICU's effectiveness has been validated in external datasets, and it provides a user-friendly online tool to improve mortality risk assessment among cancer patients in ICU settings.
Increased oxidative phosphorylation (OXPHOS) and reactive oxygen species (ROS) levels are inherently linked. ROS are essential signaling molecules, with detrimental effects when produced in excess during chemotherapy, leading to cell death. Cancer stem-like cells (CSCs) are a subpopulation of tumor cells resistant to chemotherapy, highly invasive and metastagenic, driving malignant cancer behavior.
View Article and Find Full Text PDFInflammasomes are a multi-protein platform forming a part of the innate immune system. Inflammasomes are at standby status and can be activated when needed. Inflammasome activation is an important mechanism for the production of active interleukin (IL)-1β and IL-18, which have important roles to instruct adaptive immunity.
View Article and Find Full Text PDFMitochondria-centric bioenergetic characteristics in cancer stem-like cells.
Arch Pharm Res
February 2019
Metabolic and genotoxic stresses that arise during tumor progression and anti-cancer treatment, respectively, can impose a selective pressure to promote cancer evolution in the tumor microenvironment. This process ultimately selects for the most "fit" clones, which generally have a cancer stem cell like phenotype with features of drug resistance, epithelial-mesenchymal transition, invasiveness, and high metastatic potential. From a bioenergetics perspective, these cancer stem-like cells (CSCs) exhibit mitochondria-centric energy metabolism and are capable of opportunistically utilizing available nutrients such as fatty acids to generate ATP and other metabolic substances, providing a selective advantage for their survival in an impermissible environment and metabolic context.
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