Publications by authors named "Minke Rijpkema"
Article Synopsis
- Advanced in vitro heart models are essential for better disease modeling and drug testing, as current models have limitations in cell complexity and structure.
- This study introduces a new Heart-on-Chip (HoC) model that combines different heart cell types and mimics the heart's physiological environment through specialized flow conditions.
- The resulting miniaturized micro-EHTs show improved heart muscle performance and altered drug responses, indicating that these complex models can enhance drug testing and therapeutic research.
Endothelialized in vitro models for cardiovascular disease have contributed greatly to our current understanding of the complex molecular mechanisms underlying thrombosis. To further elucidate these mechanisms, it is important to consider which fundamental aspects to incorporate into an in vitro model. In this review, we will focus on the design of in vitro endothelialized models of thrombosis.
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