Senescence Reprogramming by MTHFD2 Deficiency Facilitates Tumor Progression.

Age is a critical risk factor for cancer, as its incidence and mortality increase with age. However, there is limited understanding of the molecular changes aging induces in tumors. We explored demographic differences between young and old cancer patients and identified age sixty and above as pivotal in cancer prognosis.

Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer.

Accumulating evidence indicates that gut microbiota dysbiosis contributes to colorectal cancer and adenoma. However, a few studies revealed the altered gut mycobiota architecture in colorectal cancer. The present study characterized the gut mycobiota profiles in adenoma and colorectal cancer patients by metagenomic sequencing.