PD-L1 regulates tumor proliferation and T-cell function in NF2-associated meningiomas.

Introduction: Programmed death-ligand 1 (PD-L1) expression is an immune evasion mechanism that has been demonstrated in many tumors and is commonly associated with a poor prognosis. Over the years, anti-PD-L1 agents have gained attention as novel anticancer therapeutics that induce durable tumor regression in numerous malignancies. They may be a new treatment choice for neurofibromatosis type 2 (NF2) patients.

Impact of Molecular Subgroups on Prognosis and Survival Outcomes in Posterior Fossa Ependymomas: A Retrospective Study of 412 Cases.

Background And Objectives: Posterior fossa ependymomas (PFEs) are rare brain tumors classified as PF-EPN-A (PFA) and PF-EPN-B (PFB) subgroups. The study aimed to evaluate the prognosis and survival outcomes in PFEs, with a focus on the impact of molecular subgroups.

Methods: A retrospective study was conducted on 412 patients with PFEs.

Auditory brainstem implants for hearing rehabilitation in NF2-schwannomatosis: A systematic review and single-arm meta-analysis.

Background: NF2-schwannomatosis (NF2) is an autosomal dominant disorder prone to hearing loss. Auditory brainstem implants (ABIs) offer a promising solution for hearing rehabilitation in NF2.

Objective: To synthesize existing literature on ABI implantation in NF2, focusing on audiological outcomes and ABI-related complications.

Multiple Kernel Learning Based Classification of Parkinson's Disease With Multi-Modal Transcranial Sonography.

Parkinson's Disease (PD) is the most common motor neurodegenerative disease in elderly population. Transcranial sonography (TCS) has become a popular imaging tool for diagnosis of PD in clinical practice. Moreover, several pioneering work have developed the computer-aided diagnosis (CAD) for PD with the transcranial B-mode sonography (TBS).

Sub-Poissonian shot noise of a high internal gain injection photon detector.

The noise performance of an infrared injection photon detector with very high internal gain was investigated at a wavelength of 1.55 mum. The devices showed sub-Poissonian shot noise with Fano factors around 0.