Quinoa bran polyphenol extract attenuates high-fat diet induced non-alcoholic fatty liver disease in mice.

Quinoa bran is a by-product of quinoa processing and is rich in polyphenolic bioactives. Previous studies have shown that polyphenol compounds can help alleviate metabolic diseases, but studies on quinoa bran polyphenols intervening in non-alcoholic fatty liver disease (NAFLD) have not yet been reported. In this study, a C57BL/6J mouse NAFLD model was established using a high-fat diet (HFD) to explore the interventional effects of quinoa bran polyphenol extract (QBP) on NAFLD in mice.

Molecular dynamics modeling of different conformations of beta-glucan, molecular docking with dectin-1, and the effects on macrophages.

This study investigated β-glucan with diverse conformations by using molecular dynamics simulations to analyze their conformational transitions in water. Stable conformations were docked with the Dectin-1 protein to evaluate key metrics such as favorable conformations, root-mean-square deviation, hydrogen bond interactions, and their effects on macrophage activity. Results revealed that single-chain β-1,3-glucan with a degree of polymerization (DP) of 24 forms aggregates in water, while triple-chain β-1,3-glucan with a DP of 6 tends to form double helices.

The effect of stir-frying on the aging of oat flour during storage: A study based on lipidomics.

In this study, we used the LC-ESI-MS/MS technique to elucidate the effects of stir-frying on the lipidomics of oat flour before and after storage. We detected 1540 lipids in 54 subclasses; triglycerides were the most abundant, followed by diacylglycerol, ceramide (Cer), digalactosyldiacylglycerol, cardiolipin, and phosphatidylcholine. Principal component analysis and orthogonal least squares discriminant analysis analyses showed that oat flour lipids were significantly different before and after storage in stir-fried oat flour and raw oat flour.

A ratiometric fluorescence platform based on carbon dots for visual and rapid detection of copper(II) and fluoroquinolones.

A simple smartphone-integrated ratiometric fluorescent sensing system for visual determination of copper ions (Cu) and fluoroquinolones (FQs) was developed based on carbon dots (CDs) which were synthesized through the high-temperature pyrolysis of citric acid. In this system, with the fluorescence resonance energy transfer effect between CDs and 2,3-diaminophenazine (oxOPD), the detection of Cu and ciprofloxacin (CIP, an example for FQs) was realized. Cu catalyzes the oxidation of OPD to form oxOPD with yellow fluorescence, resulting in the quenching of CDs.

A fluorescent and colorimetric dual-recognition probe based on copper(II)-decorated carbon dots for detection of phosphate.

In the present article, we report a novel fluorescent and colorimetric dual-signal sensing probe based on a CD-Cu complex for the detection of the phosphate ion (Pi). The yellow fluorescent carbon quantum dots (CDs) were simply synthesized one-step hydrothermal treatment of -phenylenediamine (OPD) and 4-aminobutyric acid (GABA). The method was based on the combination of the CDs and Cu to form a coordination complex.

A highly sensitive ratiometric fluorescent sensor for copper ions and cadmium ions in scallops based on nitrogen doped graphene quantum dots cooperating with gold nanoclusters.

Based on the electrostatic interaction, we constructed a ratiometric fluorescence nanomixture of graphene quantum dots-gold nanoclusters (GQDs-AuNCs) for the quantitative detection of Cu and Cd. When Cu or Cd was added into the reaction system, the fluorescence of GSH-AuNCs at 565 nm can be quenched by Cu and enhanced by Cd while the intensity of N-GQDs at 403 nm stayed constant. Under the optimized conditions, the fluorescence intensity ratio (I/I) of the GQDs-AuNCs system was proportional to the concentration of Cu and Cd in the range of 8×10 mol/L-6×10 mol/L and 1×10 mol/L-4×10 mol/L, respectively, with detection limits of 4.