Publications by authors named "Ministrini S"
Article Synopsis
- Cardiogenic shock (CS) is a major cause of in-hospital deaths after acute coronary syndromes (ACS), with nearly 50% mortality, highlighting the need for personalized risk prediction.
- The ORBI score, designed to predict in-hospital CS in ACS patients undergoing percutaneous coronary intervention (PCI), has shown varying effectiveness between genders, necessitating improved risk assessment methods.
- A new score called SEX-SHOCK was developed, incorporating key health indicators, and demonstrated better predictive ability for both sexes compared to the ORBI score, thus advancing risk prediction strategies in ACS management.
Background And Aims: Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndrome (ACS).
Methods: Proenkephalin was measured in plasma in a prospective multicentre ACS cohort from Switzerland (n = 4787) and in validation cohorts from the UK (n = 1141), Czechia (n = 927), and Germany (n = 220).
Due to its peculiar structure and function, the cardiovascular system is particularly vulnerable to the detrimental effects of ageing. Current knowledge about the molecular mechanisms of ageing revealed the processes actively promoting ageing, e.g.
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- - Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder caused by a mutation in the lamin A gene (LMNA), leading to premature aging and increased risk of cardiovascular events in affected children.
- - Research using Lmna mutant mice showed that these animals formed blood clots more quickly than normal mice, with higher platelet activation and altered factors involved in blood clotting.
- - The study suggests that the LMNA mutation contributes to faster thrombus formation due to enhanced platelet reactivity, highlighting the need for further research on antiplatelet treatments for children with HGPS to reduce their risk of cardiovascular complications.
Article Synopsis
- * The study examined the effects of tafamidis on tissue factor (TF) expression and activity in human aortic endothelial cells (HAECs), revealing that tafamidis significantly reduces TF levels when induced by inflammatory signals.
- * This reduction in TF activity suggests that tafamidis may help lower the risk of blood clots (thromboembolic complications) in patients with ATTR cardiomyopathy, providing insights into its potential benefits beyond just stabilizing TTR.
Background: Personalized medicine represents a novel and integrative approach that focuses on an individual's genetics and epigenetics, precision medicine, lifestyle and exposures as key players of health status and disease phenotypes.
Methods: In this narrative review, we aim to carefully discuss the current knowledge on gender disparities in cardiometabolic diseases, and we consider the sex- specific expression of miRNAs and their role as promising tool in precision medicine.
Results: Personalised medicine overcomes the restricted care of patient based on a binomial sex approach, by enriching itself with a holistic and dynamic gender integration.
Article Synopsis
- Interest in metastatic gastric cancer is rising, with the META-GASTRO registry aiming to gather clinical data on oligometastatic patients to guide multimodal treatment, including surgery.
- The study analyzed data from 383 patients, identifying oligometastatic cases through two definitions: quantitative/anatomical (specific site metastases) and dynamic (percentage based on site), finding relevant statistical significance.
- The results indicated that 30% of patients fit the quantitative definition and 16% the dynamic definition, with outcomes for conversion therapy similar to those who had surgery after initial chemotherapy.
Article Synopsis
- The Italian Research Group for Gastric Cancer created a database to assess how a practical approach influences stage IV gastric cancer management and patient outcomes.
- Data from 383 patients collected between 2018 and September 2022 showed increased use of laparoscopic techniques and a significant difference in surgical treatment strategies compared to past practices.
- The study found that while different metastatic sites didn't significantly affect survival rates, having multiple sites did worsen survival, indicating that better diagnosis and staging can improve outcomes for patients eligible for curative surgery.
Introduction: Differential expression of long non-coding RNAs (lncRNAs) is a hallmark of cardiovascular aging, cerebrovascular diseases, and neurodegenerative disorders. This research article investigates the association between a panel of lncRNAs and the risk of death and ischemic stroke in a cohort of non-institutionalized elderly subjects.
Method: A total of 361 healthy individuals aged 75 years old, prospectively recruited in the Vienna Transdanube Aging (VITA) cohort, were included.
Aims: Despite advances in pharmacotherapy and device innovation, in-stent restenosis (ISR) and stent thrombosis (ST) remain serious complications following percutaneous coronary intervention (PCI) procedure with stent implantation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme involved in plasma cholesterol homeostasis and recently emerged as a therapeutic target for hypercholesterolemia. Antibody-based PCSK9 inhibition is increasingly used in different subsets of patients, including those undergoing PCI.
View Article and Find Full Text PDFBackground And Aims: Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of angiotensin II which disturbs peripheral blood pressure regulation and compromises left ventricular function. This study examined the relationship of circulating DPP3 (cDPP3) with cardiogenic shock (CS) and mortality in patients presenting with acute coronary syndromes (ACS).
Methods: Plasma cDPP3 levels were assessed at baseline and 12-24 h after presentation in patients with ACS prospectively enrolled into the multi-centre SPUM-ACS study (n = 4787).
Diabetic cardiomyopathy (DbCM) is characterized by restrictive pattern and consistent risk of overt heart failure. We here focused osteopontin (OPN), which was tested independently associated with left ventricular diastolic dysfunction (LVDD). Overall, OPN increased with DbCM severity according with the presence of left atrial dilatation, LV hypertrophy and LVDD.
View Article and Find Full Text PDFBackground: Spore Trap is an environmental detection technology, already used in the field of allergology to monitor the presence and composition of potentially inspirable airborne micronic bioparticulate. This device is potentially suitable for environmental monitoring of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in hospital, as well as in other high-risk closed environments. The aim of the present study is to investigate the accuracy of the Spore Trap system in detecting SARS-CoV-2 in indoor bioaerosol of hospital rooms.
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- The study investigates sclerostin (SOST) as a potential biomarker for sepsis management, particularly in predicting patient outcomes.
- SOST levels were measured in 73 elderly septic patients, with findings indicating that higher SOST levels are linked to increased 30-day mortality risk and are more predictive than traditional scoring systems.
- Over a median follow-up of 2.5 years, SOST showed a significant decline in levels, and this change further correlated with long-term mortality, suggesting its importance in assessing both short- and long-term health outcomes in septic patients.
The healthy human heart has special directional arrangement of cardiomyocytes and a unique electrical conduction system, which is critical for the maintenance of effective contractions. The precise arrangement of cardiomyocytes (CMs) along with conduction consistency between CMs is essential for enhancing the physiological accuracy of cardiac model systems. Here, we prepared aligned electrospun rGO/PLCL membranes using electrospinning technology to mimic the natural heart structure.
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- This study looks at how a protein called JCAD affects problems in the heart, specifically related to blood clotting and artery health.
- Researchers used special mice without JCAD to see how they reacted to injuries in their blood vessels and found that these mice had fewer blood clots forming.
- In people with heart issues, higher levels of JCAD were linked to more problems with blood clotting, suggesting that JCAD is important in how our bodies respond to blood vessel injuries.
In a murine model of acute ischemic stroke, SIRT6 knockdown resulted in larger cerebral infarct size, worse neurological outcome, and higher mortality, indicating a possible neuro-protective role of SIRT6. In this study, we aimed at evaluating the prognostic value of serum SIRT6 levels in patients with acute ischemic stroke (AIS). Serum levels of SIRT6, collected within 72 h from symptom-onset, were measured in 317 consecutively enrolled AIS patients from the COSMOS cohort.
View Article and Find Full Text PDFDeep vein thrombosis (DVT) in critically ill patients still represents a clinical challenge. The aim of the study was to investigate whether a systematic ultrasound (US) screening might improve the management of the antithrombotic therapy in intensive care unit (ICU). In this non-randomized diagnostic clinical trial, 100 patients consecutively admitted to ICU of the University Hospital of Perugia were allocated either in the screening group or in the control group.
View Article and Find Full Text PDFAims: Low-grade inflammation couples dysmetabolic states to insulin resistance and atherosclerotic cardiovascular (CV) disease (ASCVD). Selective sodium-glucose co-transporter 2 (SGLT-2) inhibition by empagliflozin improves clinical outcomes in patients with ASCVD independently of its glucose lowering effects. Yet, its mechanism of action remains largely undetermined.
View Article and Find Full Text PDFThe improvements in healthcare services and quality of life result in a longer life expectancy and a higher number of aged individuals, who are inevitably affected by age-associated cardiovascular (CV) diseases. This challenging demographic shift calls for a greater effort to unravel the molecular mechanisms underlying age-related CV diseases to identify new therapeutic targets to cope with the ongoing aging "pandemic". Essential for protection against external pathogens and intrinsic degenerative processes, the inflammatory response becomes dysregulated with aging, leading to a persistent state of low-grade inflammation known as inflamm-aging.
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