[Myocardial infarction of rare etiology in a young adult].

Chest pain is not uncommon among young patients below the age of 35 years, however, it is rarely caused by acute coronary syndrome. The rarity of coronary artery occlusion in this population can easily lead to diagnostic mistakes. The authors present the case history of a 19-year-old young female, who was admitted to the emergency department of a local hospital due to the sudden onset of chest pain and malaise.

[Pure 46,XY gonadal dysgenesis].

The authors report a rare case of pure 46,XY gonadal dysgenesis (Swyer syndrome). Swyer syndrome is associated with 46,XY karyotype, primary amenorrhea as well as the presence of female internal genital tract and bilateral streak gonads in a phenotypic female. The genetic background of this syndrome includes mutations of several genes involved in the testis differentiation cascade.

[Prevalence of celiac disease in Turner syndrome].

Introduction And Aim: Percentage of coeliac disease among patients with Turner syndrome is given differently in a few publication. The aim of the study was to assess prevalence of celiac disease in Turner syndrome.

Patients And Methods: Serological screening of coeliac disease were performed in 63 patients with Turner syndrome during the last 11.

[Changing trends in breast surgery over a five year period (1998-2002)--a retrospective analysis].

Today's development in breast cancer surgery are characterized by the principle of the smallest necessary intervention in contrast with the radicality of the past. To achieve this goal the primary and crucial task is the recognition of early (stage I or II) breast cancer. The National Screening Program started 2002 provides ideal conditions.

[The role of repeated biopsies in prognosis of prostate cancer].

Introduction: The treatment of prostate cancer is still controversial. One of the most common treatment form is the use of LHRH analogs, but its way of action is still not cleared enough.

Aims: The aim of this study was to determine the predictive value of some histological and immuno-histochemical parameters based on repeated biopsies taken from prostate carcinoma patients.

Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma.

Background: Apoptosis is one of the major events following total androgen blockade (TAB). The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients.

Methods: At the time of diagnosis by needle biopsy TNM stage, serum PSA, Gleason's grade, apoptotic and mitotic index, Ki67, p53, and bcl(2) expression were investigated in 60 prostate carcinoma patients.

[Precocious puberty caused by a testicular Leydig cell tumor].

Testicular tumors are very rare in boys, approximately 1.5% of these are Leydig cell tumors. The authors present a 4.

New human Dirofilarioses in Hungary.

About ten cases of filariosis have recently been recorded in the Hungarian medical literature, six of them caused by Dirofilaria repens. Dirofilaria repensis a mosquito-transmitted filaroid worm in the subcutaneous tissue of dogs and cats in the temperate areas of the Old World. It accidentally infects man, too, and can remain unidentified due to physicians, poor knowledge of the parasite.

Multicentric Castleman disease and systemic lupus erythematosus phenotype in a boy with Klinefelter syndrome: long-term disease stabilization with interferon therapy.

An 11-year-old boy with Klinefelter syndrome had Castleman disease (CD) of plasma cell type develop. Nonregulated antibody production mimicked systemic lupus erythematosus (SLE). Hepatitis C virus (HCV) infection caused significant disease worsening.

[Complex screening of family members at risk for familial adenomatous polyposis].

151 members of 10 affected families with FAP have been registered at the authors' regional polyposis registry, among them 51 FAP patients were verified histologically. The disorder is autosomal dominant thus the chance for the inheritance of the mutated allele is fifty percent in the offspring of an affected patient. Because of the high risk the registration and regular control of family members is recommended.

Difficulties in early diagnosis and treatment of uncommon breast tumours.

The aim of the current study was to analyse the uncommon histological type tumours, occurred in our department in the last 10 years. In the study period 921 patients were treated for breast malignoma, 47.4% of them in early cancer stage.

The Clinical Significance of the Primary Malignant Melanoma of the Lower Respiratory Tract and/or Lung Based on the Analysis of Published Case Reports and of Two Patients.

Considering the data and including two patients of the authors, there exist only 18 authentic cases of primary malignant melanoma of the lower respiratory tract and/or the lung. The tumor was localized in the endobronchial space in 7 cases and only once in the trachea. Endobronchial localization, together with the involvement of the surrounding lung tissue, was found in two cases, whereas in 8 patients, the tumor was found exclusively in the lung parenchyma.

[Primary malignant melanoma of the lung and lower respiratory tract].

After detailed analysis of the international special literature, the authors found--together with their own two patients--only 18 cases, considered primer malignant melanoma of the lower respiratory tract and/or lung. Of the accepted criteria, they dispute the obduction's absolute evidentiary role, because among primer patients there are the most who survives, even a decade. In seven cases tumour was located endobronchially and in one patient in the trachea.

[Behavior of adamantinoma of the long bones based on long-term follow up studies].

Authors report on the long time (in average 12 years, range: 5-36 years) follow-up results of 5 cases of adamantinoma, localized on the tibia. In one case recurrence was found very late, 20 and 36 years after the primary wide resection, and resection was repeatedly performed. Because of problems of differential diagnosis in one case the tumor was excised intralesionally (curettage + plasty with cancellous bone).

Bronchial papillomas of various origins.

There were five cases of solitary papillomas and three of chronic infectious papillomatosis induced by a foreign body, one caused by broncholithiasis. The five isolated papillomas had verrucous appearances. The common opinion, that the solitary papilloma is likely to be a pedunculary tumor, seems untrue.

Screening for colorectal cancer in a Hungarian county.

An initial screening for colorectal cancer in asymptomatic adults was performed with Haemoccult in 26,357 persons, rigid rectoscopy in 10,673 and flexible sigmoidoscopy in 3,963 persons. The rate of cancer detection was 4.4% in screenees with a positive Haemoccult test, 0.

Carcinoid tumours of the rectum.

Carcinoid tumours of the rectum occur relatively seldom. The personal experience was 11/20,0000 rectoscopies. The symptoms are not characteristic.

Colitis carcinoma in ulcerative colitis.

During the period from 1963 till 1981 altogether 342 patients suffering from ulcerative colitis were treated. In their material authors found 6 patients (1.7%) who achieved cancer of the colon beginning 7, 9, 14, 18, 18 und 21 years after the onset of ulcerative colitis symptoms.