Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability.

Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free deoxy-ribonucleoside triphosphates (dNTPs). How these metabolic processes are integrated to fuel tumorigenesis remains to be investigated.

Neuroprotective Iridoids and Lignans from .

() is widely distributed in Northeast China. In addition to medicines, it has also been used to prepare food, wine, tobacco, cosmetics, perfume, and functional foods. Other studies have investigated the neuroprotective effects of extract.

An Effective Chromatography Process for Simultaneous Purification and Separation of Total Lignans and Flavonoids from .

An effective chromatography process was developed and validated for simultaneous purification and separation of total lignans and flavonoids from . The total lignans and flavonoids in extract were prepurified with macroporous resin column chromatography, and the conditions were optimized as follows: 40 mg/mL extract (2.0 g) solution was loaded onto an AB-8 resin column with a diameter-to-height ratio of 1:7, followed by adsorption for 6 h; then, the column was eluted successively with 5 BV water and 10% and 50% ethanol at a flow rate 2 BV/h.

The potential of as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry.

plants are members of the family, which include more than 200 species worldwide. We summarized previous reports on traditional clinical applications, bioactivities, and phytochemistry of by searching electronic databases of Science Direct, Web of Science, PubMed, and some books. Some species have been used as traditional medicines, demonstrating calming fright and tranquilizing mind, promoting Qi and blood, activating blood circulation and regulating menstruation, dispelling wind and eliminating dampness, regulating Qi-flowing to relieve pain, and promoting digestion and checking diarrhea, and treating diseases of the nervous, cardiovascular, and digestive systems, inflammation, gynecology, and others.

Designing nitrogen-enriched echinus-like carbon capsules for highly efficient oxygen reduction reaction and lithium ion storage.

Both structural and compositional modulations are important for high-performance electrode materials in energy conversion/storage devices. Here hierarchical-structure nitrogen-rich hybrid porous carbon capsules with bamboo-like carbon nanotube whiskers (N-CC@CNTs) grown in situ have been specifically designed, which combine the advantageous features of high surface area, abundant active sites, easy access to medium and favorable mass transport. As a result, the newly prepared N-CC@CNTs show highly efficient catalytic activity in oxygen reduction reaction in alkaline media for fuel cells, which not only outperforms commercial Pt-based catalysts in terms of kinetic limiting current, stability and tolerance to methanol crossover effect, but is also better than most of the nanostructured carbon-based catalysts reported previously.