Publications by authors named "Minhuan Lin"
Epigenetic regulation is an important entry point to study the pathogenesis of selective fetal growth restriction (sFGR), and an understanding of the role of long noncoding RNAs (lncRNAs) in sFGR is lacking. Our study aimed to investigate the potential role of a lncRNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), in sFGR using molecular biology experiments and gain- or loss-of-function assays. We found that the levels of MALAT1, ERRγ, and HSD17B1 were downregulated and that of miR-424 was upregulated in the placental shares of the smaller twins.
View Article and Find Full Text PDFObjectives: To compare the clinical outcomes of different multifetal pregnancy reduction (MFPR) programs in dichorionic (DC) triplets, and explore the association between early ultrasound characteristics and co-twin death after potassium chloride (KCl) injection into one monochorionic (MC) twin.
Methods: We retrospectively reviewed the data of DC triplets who underwent MFPR at our center during 2012-2021. Patients were grouped as follows: intracardiac KCl injection into one MC twin (group A), intracardiac KCl injection into both MC twins simultaneously (group B), and reduction of the singleton fetus (group C) and pregnancy outcomes were compared.
Fetal growth restriction (FGR) is a placenta-mediated pregnancy complication that predisposes fetuses to perinatal complications. Maternal plasma cell-free DNA harbors DNA originating from placental trophoblasts, which is promising for the prenatal diagnosis and prediction of pregnancy complications. Extrachromosomal circular DNA (eccDNA) is emerging as an ideal biomarker and target for several diseases.
View Article and Find Full Text PDFWhen a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole.
BMC Pregnancy Childbirth
October 2021
Article Synopsis
- Hydatidiform moles are characterized by multiple vesicles in the placenta, and recent cytogenetic advancements have aided in better diagnosis and understanding of their complexities.
- A 33-year-old woman faced a rare case of a coexisting hydatidiform mole and a healthy fetus at 24 weeks, leading to a complex diagnosis that was confirmed only through advanced genetic testing after initial assessments didn’t clarify the situation.
- This case emphasizes the need for tailored care and additional diagnostic methods beyond traditional imaging when dealing with pregnancies involving abnormal placental formations alongside a live fetus.
Background: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive lipid disorder often associated with recurrent episodes of pancreatitis. It is documented in most cases with FCS due to the mutations of key proteins in lipolysis, including LPL, APOC2, APOA5, LMF1 and GPIHBP1.
Case Presentation: We report the successful management of a 35-year-old pregnant woman carrying a novel homozygous frameshift mutation c.