Publications by authors named "Minhua Yao"

Background: Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mediated by IgE and involving a variety of immune cells such as mast cells. In previous studies, AR was considered as an isolated disease of the immune system. However, recent studies have found that the nervous system is closely related to the development of AR.

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Long non-coding RNA has been shown to mediate the progression of polycystic ovary syndrome (PCOS). However, the role and mechanism of Prader-Willi region nonprotein coding RNA 2 (PWRN2) in PCOS progression remain unclear. In our study, Sprague-Dawley rat was injected with dehydroepiandrosterone to mimic PCOS rat models.

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Cystic fibrosis (CF) is a life-threatening autosomal-recessive disease caused by mutations in a single gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CF effects multiple organs, and lung disease is the primary cause of mortality. The median age at death from CF is in the early forties.

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Article Synopsis
  • - Myeloid-derived suppressor cells (MDSCs) are diverse cells that accumulate abnormally from myeloid cell differentiation and primarily function to suppress T cell activity, allowing tumors to evade the immune system.
  • - The goal of immunotherapy is to enhance the immune system’s ability to fight tumors, but MDSCs pose a significant challenge by decreasing the effectiveness of these treatments and increasing tumor cell resistance.
  • - This review examines the roles and mechanisms of MDSCs in the tumor microenvironment, explores immunotherapy strategies targeting MDSCs, and discusses potential advances in combining these therapies with immune checkpoint blockade for better cancer treatment outcomes.
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells derived from bone marrow that play critical immunosuppressive functions in the tumor microenvironment (TME), promoting cancer progression. According to base length, Non-coding RNAs (ncRNAs) are mainly divided into: microRNAs (miRNAs), lncRNAs, snRNAs and CircRNAs. Both miRNA and lncRNA are transcribed by RNA polymerase II, and they play an important role in gene expression under both physiological and pathological conditions.

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Livestock farming development has become increasingly important in recent years. It not only provides us with meat nutrition and pet feeding but also increases the economic value by providing numerous employment opportunities, which improves our life quality. The livestock farming development depends on successful animal reproduction.

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Background: Germinal vesicle (GV) chromatin configurations of oocytes are proposed to be related to oocyte competence and may reflect the quality of oocyte. Currently, a limited number of published studies investigated the GV chromatin configurations of guinea pig oocytes.

Objective: In this study on the in vitro maturation (IVM) of guinea pig oocytes, we examined the changes in their GV chromatin configurations during meiotic progression.

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Objective: To verify the clinical efficacy of Xiaochuangao acupoint paste (XAP) in treating asthma in children.

Method: Ninety children patients with asthma were randomly assigned to three groups with 30 patients each, being treated with XAP, hormone and XAP combined with hormone, respectively. The changes of the lung function and the recurrence times during one-year follow-up were observed.

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Objective: To study whether Modified Sijunzi Decoction (MSD) has protective effects on the intestinal mucosal barrier function of giant colon children.

Methods: Thirty-two giant colon children patients were randomly assigned to two groups. Patients in the treatment group (16 cases) took MDS after cleaning edema, while cleaning enema was given to those in the control group 10 days before operation.

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Objective: The objective of this study was to investigate the effect of a gastric side purse-string technique on anastomotic strictures during esophageal carcinoma operations.

Methods: From 1996 to 2005, esophageal carcinoma operations were performed on 1128 consecutive patients. Among them, 463 underwent esophagogastric anastomosis with purse-string sutures on the gastric side (purse group) and the other 665 did not (nonpurse group).

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Synopsis of recent research by authors named "Minhua Yao"

  • - Minhua Yao's recent research primarily investigates the intersection of immune and neurological systems in various diseases, notably allergic rhinitis, highlighting the complex interplay between the nervous system and immune responses in inflammatory conditions.
  • - The author also explores the role of long non-coding RNAs, particularly PWRN2, in the progression of polycystic ovary syndrome, shedding light on epigenetic influences on disease mechanisms.
  • - Additionally, Yao focuses on advancements in reproductive biology, including optimizing in vitro maturation systems for guinea pig oocytes and studying the effect of chromatin configurations on oocyte quality, which is vital for enhancing reproductive techniques in livestock.