Causal relationship between the composition of the Gut Microbiota and central precocious puberty: a two-sample Mendelian randomization study.

Background: Previous observational research has demonstrated a possible association between the gut microbiota (GM) and central precocious puberty (CPP). Nevertheless, whether there is a causal relationship between the GM and CPP is uncertain due to the possibility of confounding factors influencing the result.

Methods: We collected summary data from genome-wide association studies of the GM (MiBioGen,  = 18,340) and CPP (FinnGen Consortium, 185 case groups and 395,289 controls).

Fondaparinux sodium combined with conventional therapy improves subchorionic hematoma with protein S deficiency.

Background: Fondaparinux sodium can prevent and treat acute illnesses and venous thromboembolism in patients undergoing surgery. At present, no studies have reported on treating subchorionic hematoma combined with protein S deficiency using fondaparinux sodium.

Objective: To investigate the clinical efficacy of fondaparinux sodium in the treatment of patients with subchorionic hematoma combined with protein S deficiency.

Nephrotoxicity of immune checkpoint inhibitor combination therapy in patients with advanced renal cell carcinoma: a meta-analysis.

Purpose: Few data are available regarding the nephrotoxicity of immune checkpoint inhibitor (ICI) combination therapy in advanced renal cell carcinoma (RCC). This study aimed to investigate the nephrotoxicity of ICI-based combination therapy versus standard of care sunitinib in patients with advanced RCC.

Methods: We searched Embase/PubMed/Cochrane Library for relevant randomized controlled trials (RCTs).

Comparison of Common Methods for Precision Volume Measurement of Hematoma.

Purpose: Our aim is to conduct analysis and comparison of some methods commonly used to measure the volume of hematoma, for example, slice method, voxelization method, and 3D-Slicer software method (projection method).

Method: In order to validate the accuracy of the slice method, voxelization method, and 3D-Slicer method, these three methods were first applied to measure two known volumetric models, respectively. Then, a total of 198 patients diagnosed with spontaneous intracerebral hemorrhage (ICH) were recruited.

Three-dimensional protein model similarity analysis based on salient shape index.

Background: Proteins play a special role in bioinformatics. The surface shape of a protein, which is an important characteristic of the protein, defines a geometric and biochemical domain where the protein interacts with other proteins. The similarity analysis among protein models has become an important topic of protein analysis, by which it can reveal the structure and the function of proteins.