Air pollution is an environmental risk factor linked to multiple human diseases including cardiovascular diseases (CVDs). While particulate matter (PM) emitted by diesel exhaust damages multiple organ systems, heart disease is one of the most severe pathologies affected by PM. However, the in vivo effects of diesel exhaust particles (DEP) on the heart and the molecular mechanisms of DEP-induced heart dysfunction have not been investigated.
View Article and Find Full Text PDFTraffic related non-tailpipe particulate matter emissions can rival the continuously decreasing tailpipe emissions in modern fleets. Non-tailpipe emissions have become the dominating source of traffic emissions in California already. This study measured ambient PM and PM concentrations at near road environments for two major highways in California, I-5 in Anaheim and I-710 in Long Beach.
View Article and Find Full Text PDFDiesel exhaust particles (DEP) are risk factors for endothelial cells (ECs) dysfunction. However, the mechanism by which DEP induce ECs apoptosis remains unclear. Here, we investigated how DEP induce death of human umbilical vein ECs (HUVECs), with a focus on the autophagy-mediated apoptotic pathway.
View Article and Find Full Text PDFParticulate matter (PM) causes several diseases, including cardiovascular diseases (CVDs). Previous studies compared the gene expression patterns in airway epithelial cells and keratinocytes exposed to PM. However, analysis of differentially expressed gene (DEGs) in endothelial cells exposed to PM2.
View Article and Find Full Text PDFFine dust (PM2.5) is generated from various sources, and many studies have reported on the sources of PM2.5.
View Article and Find Full Text PDFThe oxidative potential (OP) and chemical characteristics of fine particles collected from urban, roadside, rural, and industrial sites in Korea during spring, summer, fall, and winter seasons and an urban site in the Philippines during dry and wet seasons were examined. Significant differences in the OP of fine particles among sites and seasons were found. The industrial site yielded the highest OP activity (both mass and volume-normalized OP) among the sites, suggesting the strongest reactive oxygen species (ROS)-generating capability of industry source-dominant PM.
View Article and Find Full Text PDF