Publications by authors named "Minhan Park"

Article Synopsis
  • Understanding the health effects of fine particulate matter (PM) requires toxicological data and exposure levels, especially focusing on their oxidative potential (OP) and cell toxicity in urban areas like Beijing and Gwangju.
  • The study found that the oxidative potential (OP) and cell toxicity were influenced by chemical components such as acids and benzocarboxylic acids, with OP showing more variation across different locations and seasons.
  • A new health index was created using OP, cell toxicity, and PM concentration, which can help predict health effects from PM pollution based on its chemical sources, rather than just measuring PM levels alone.
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Air pollution is an environmental risk factor linked to multiple human diseases including cardiovascular diseases (CVDs). While particulate matter (PM) emitted by diesel exhaust damages multiple organ systems, heart disease is one of the most severe pathologies affected by PM. However, the in vivo effects of diesel exhaust particles (DEP) on the heart and the molecular mechanisms of DEP-induced heart dysfunction have not been investigated.

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Traffic related non-tailpipe particulate matter emissions can rival the continuously decreasing tailpipe emissions in modern fleets. Non-tailpipe emissions have become the dominating source of traffic emissions in California already. This study measured ambient PM and PM concentrations at near road environments for two major highways in California, I-5 in Anaheim and I-710 in Long Beach.

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Article Synopsis
  • Regional air pollution in Northeast Asia is rising due to increased energy consumption from population growth and industrialization, with a study focusing on fine particulate matter (PM) sampling in Korea and China.* -
  • The analysis showed that the main sources of PM in Korea included secondary nitrates, secondary sulfates, and biomass burning, while in China, dust and coal combustion were significant contributors.* -
  • The study found that aged PM with secondary products increases oxidative potential, highlighting the need for actions to mitigate the effects of long-range PM transport on air quality.*
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Diesel exhaust particles (DEP) are risk factors for endothelial cells (ECs) dysfunction. However, the mechanism by which DEP induce ECs apoptosis remains unclear. Here, we investigated how DEP induce death of human umbilical vein ECs (HUVECs), with a focus on the autophagy-mediated apoptotic pathway.

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Particulate matter (PM) causes several diseases, including cardiovascular diseases (CVDs). Previous studies compared the gene expression patterns in airway epithelial cells and keratinocytes exposed to PM. However, analysis of differentially expressed gene (DEGs) in endothelial cells exposed to PM2.

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Article Synopsis
  • Agricultural burning and forest fires in Northeast Asia contribute significantly to fine particulate pollution, affecting air quality.
  • A study showed that burning rice straw produced less fine particles and elemental carbon compared to burning pine stems.
  • Additionally, fine particles from rice straw had a higher oxidative potential and better cloud formation traits, indicating different environmental impacts between the two types of burning.
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Article Synopsis
  • The study collected ambient fine particles from Beijing and Gwangju in January 2018, analyzing organic matter (OM) using advanced mass spectrometry techniques.
  • It found that over 90% of the organic compounds consisted of carbon, hydrogen, oxygen (CHO), and those containing nitrogen (CHON), with higher CHON levels during days of elevated PM concentrations.
  • Notably, while CHON compounds in Beijing showed no correlation with certain ion species, in Gwangju, they were linked to particulate nitrate and ammonium, indicating different influences of secondary aerosols in these urban environments.
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Article Synopsis
  • Fine particulate matter (PM) less than 2.5 µm is linked to negative health effects, but toxicity levels vary based on particle size and chemical components.
  • Different sources of fine particles were assessed—including diesel and gasoline engines, biomass burning, coal combustion, and road dust—to determine their toxicity.
  • Diesel engine exhaust particles were found to be the most toxic, followed by gasoline exhaust, biomass burning, and coal, indicating that traffic is a key factor in the harmful effects of fine particles.
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The oxidative potential (OP) and chemical characteristics of fine particles collected from urban, roadside, rural, and industrial sites in Korea during spring, summer, fall, and winter seasons and an urban site in the Philippines during dry and wet seasons were examined. Significant differences in the OP of fine particles among sites and seasons were found. The industrial site yielded the highest OP activity (both mass and volume-normalized OP) among the sites, suggesting the strongest reactive oxygen species (ROS)-generating capability of industry source-dominant PM.

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