Rising Mortality of Intrahepatic Cholangiocarcinoma Among Older Adults in the United States: An Analysis of Demographic and Regional Trends.

Introduction: Intrahepatic cholangiocarcinoma (ICC) is the second most frequent primary liver malignancy after hepatocellular carcinoma. Contemporary mortality trends due to ICC are largely unknown. We aim to examine the temporal trends of ICC-related deaths among older adults in the United States from 1999 to 2022.

Door-to-Diuretic Time and Short-term Outcomes in Acute Heart Failure: A Systematic Review and Meta-analysis.

Introduction: Acute heart failure (AHF) is a leading cause of unplanned hospitalization, often associated with poor outcomes. Decongestion with intravenous loop diuretics is the mainstay of treatment. Metrics such as door-to-diuretic time, the time between presentation of AHF to the hospital, and administration of intravenous diuretics, may play an important role in faster decongestion and thereby reduce mortality.

Minimally Invasive Procedure versus Conventional Redo Sternotomy for Mitral Valve Surgery in Patients with Previous Cardiac Surgery: A Systematic Review and Meta-Analysis.

Background: The heightened morbidity and mortality associated with repeat cardiac surgery are well documented. Redo median sternotomy (MS) and minimally invasive valve surgery are options for patients with prior cardiac surgery who require mitral valve surgery (MVS). We conducted a systematic review and meta-analysis comparing the outcomes of redo MS and minimally invasive MVS (MIMVS) in this population.