Publications by authors named "Minh-Triet Hong"
The ADP-Ribosylation Factor (ARF) small GTPases have been found to act in vesicle fission through a direct ability to tubulate membrane. Here, we have used cryo-electron microscopy (EM) to solve the structure of an ARF6 protein lattice assembled on tubulated membrane to 3.9 Å resolution.
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- The endoplasmic reticulum (ER) and mitochondria interact to create mitochondria-associated ER membranes (MAMs), which are crucial for calcium (Ca) balance in neurons.
- Casein kinase 2 alpha 1 (CK2A1) plays a key role in regulating the structure and Ca transport of MAMs through its effect on PACS2 phosphorylation.
- Mutations in PACS2 linked to a specific form of epilepsy disrupt MAM integrity and disturb Ca transport, leading to increased cytosolic Ca levels and enhanced neurotransmitter release in certain brain neurons.
Dimerization of beta 2-adrenergic receptor (β-AR) has been observed across various physiologies. However, the function of dimeric β-AR is still elusive. Here, we revealed that dimerization of β-AR is responsible for the constitutive activity of β-AR generating inverse agonism.
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