A New Pathway for the Preparation of Pyrano[2,3-]pyrazoles and molecular Docking as Inhibitors of p38 MAP Kinase.

We report a new pathway to synthesize pyrano[2,3-]pyrazoles and their binding mode to p38 MAP kinase. Pyrano[2,3-]pyrazole derivatives have been prepared through a four-component reaction of benzyl alcohols, ethyl acetoacetate, phenylhydrazine, and malononitrile in the presence of sulfonated amorphous carbon and eosin Y as catalysts. All products were characterized by melting point, H and C NMR, and HRMS (ESI).