Publications by authors named "Minh-Cong Hoang"
Aldehyde dehydrogenase-1A1 (ALDH1A1), a member of a superfamily of 19 isozymes, exhibits various biological functions and is involved in several important physiological and pathological processes, including those associated with various diseases including cancers such as pancreatic cancer. Chemotherapy is one of the most important strategies for the treatment of pancreatic cancer; however, the chemoresistance exhibited by pancreatic cancer cells is a leading cause of chemotherapy failure. It has been reported that overexpression of ALDH1A1 significantly correlates with poor prognosis and tumor aggressiveness, and is clinically associated with chemoresistance.
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- * RNA therapeutics, particularly antisense oligonucleotides (ASOs), show promise in treating β-thalassemia by correcting abnormal splicing of β-globin pre-mRNA and boosting the production of functional hemoglobin.
- * The text discusses recent advancements in RNA-based therapies for β-thalassemia, highlighting their effectiveness and the challenges faced in their development and clinical application.
Article Synopsis
- * There are five main classes of RNA therapeutics: antisense oligonucleotides, small interfering RNA, microRNA, APTAMER, and messenger RNAs, which target diverse conditions that traditional drugs struggle with, including cancer and genetic diseases.
- * The chapter covers the history of RNA discoveries, their advantages, action mechanisms, approved RNA drugs, and how these therapeutics are delivered to specific organs and cells, showcasing advancements in the field.