Publications by authors named "Minh-Chau Do"

Article Synopsis
  • Valproic acid and phenytoin, common antiepileptic drugs, have narrow therapeutic indices and can cause cardiovascular and respiratory toxicity, making therapeutic drug monitoring (TDM) crucial for patient safety and treatment effectiveness.
  • A sensitive ultra-performance liquid chromatographic tandem mass spectrometer (UPLC-MS/MS) method was developed to simultaneously measure VAL and PHE in human plasma, using specific ionization techniques for accurate quantification.
  • The method demonstrated high recovery rates and met all US-FDA bioanalytical validation criteria, successfully evaluating the drug levels in plasma from epileptic patients.
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Background: Given the high rates at which patients present with behavioural health (BH) concerns in primary care (PC), this setting has become the de facto mental health system. As a result, screening for depression and other BH conditions in PC has become a critical target for improving patient outcomes. However, integration of screening into busy PC workflows can be challenging due to barriers such as limited time and resources.

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Depression in youth is prevalent and disabling and tends to presage a chronic and recurrent course of illness and impairment in adulthood. Clinical trial research in youth depression has a 30-year history, and evidence-based treatment reviews appeared in 1998 and 2008. The current review of 42 randomized controlled trials (RCTs) updates these reviews to include RCTs published between 2008 and 2014 (N = 14) and reevaluates previously reviewed literature.

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Purpose: Depression and health risk behaviors in adolescents are leading causes of preventable morbidity and mortality. Primary care visits provide prime opportunities to screen and provide preventive services addressing risk behaviors/conditions. This study evaluated the co-occurrence of depression and health risk behaviors (focusing on smoking, drug and alcohol misuse, risky sexual behavior, and obesity-risk) with the goal of informing preventive service strategies.

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