Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4-induced acute liver injury mouse model.

Background And Aim: Hepatic stellate cells (HSCs) activation, a critical event in liver fibrosis, has been recently shown to be related to autophagy. Determine whether chloroquine (CQ) could affect (i) the activation of HSC in vivo and (ii) the hepatic damage in a mice acute liver injury model.

Methods: The acute liver injury was induced in BALB/c mice by carbon tetrachloride (CCl group); 24 h before and after CCl administration animals were treated by CQ (CCl  + CQ group).