Light-Weight Deformable Registration Using Adversarial Learning With Distilling Knowledge.

Deformable registration is a crucial step in many medical procedures such as image-guided surgery and radiation therapy. Most recent learning-based methods focus on improving the accuracy by optimizing the non-linear spatial correspondence between the input images. Therefore, these methods are computationally expensive and require modern graphic cards for real-time deployment.

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.

With the aim to develop new chemical tools based on simplified natural metabolites to help deciphering the molecular mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzothiazole analogs were prepared during the synthesis of the marine benzosceptrin B. Conpounds inhibiting the RIPK1 protein kinase were discovered. A library of 54 synthetic analogs were prepared and evaluated through a phenotypic screen using the inhibition of the necrotic cell death induced by TNF-α in human Jurkat T cells deficient for the FADD protein.

Microwave-/UV-assisted Enhancement of the Wettability of Photoactive TiO Substrates Coated on an Inactive Ti/i-TiO Base.

Titanium dioxide (TiO) has been proven to be an excellent system for wettability patterning purposes because of its super hydrophilic ability and its oxidative/reductive degradation of substances when exposed to UV radiation. TiO substrates upon which was deposited a self-assembled monolayer (SAM) of n-octadecyltrimethoxysilane (ODS) shifts the surface to become super hydrophobic, which when subjected to UV irradiation causes the ODS compound to be degraded with the substrate turning back to be super hydrophilic. Such events allow wettability patterns to be easily created.

Improvement of Wettability of Photocatalytic TiO-Coated Wafers by Microwave/UV Pre-treatment.

The wettability efficiency of TiO-coated Ti substrate wafers was improved using a microwave/UV pre-treatment method. With the assistance of microwave heating, TiO substrates coating with P25 completely achieved super hydrophilic state within 5 min, which is twice as fast compared with only UV irradiation condition. Moreover, when the microwave power was increased, improvement in the wettability activity was observed.

Three-component reaction between alkynes, elemental sulfur, and aliphatic amines: a general, straightforward, and atom economical approach to thioamides.

A general, straightforward, and atom-economical three-component synthesis of thioamides from alkynes, elemental sulfur, and aliphatic amines has been developed.

Boric acid: a highly efficient catalyst for transamidation of carboxamides with amines.

A novel method of transamidation of carboxamides with amines using catalytic amounts of readily available boric acid under solvent-free conditions has been developed. The scope of the methodology has been demonstrated with (i) primary, secondary, and tertiary amides and phthalimide and (ii) aliphatic, aromatic, cyclic, acyclic, primary, and secondary amines.