Publications by authors named "Minh Huong Nguyen"
J Assist Reprod Genet
April 2015
Article Synopsis
- - Teratozoospermia is when over 85% of sperm cells have abnormal shapes, with monomorphic teratozoospermia being a rare subset that includes macrozoospermia and globozoospermia, each representing less than 1% of male infertility cases.
- - Macrozoospermia features sperm with enlarged heads and multiple tails, while globozoospermia consists of round-headed sperm lacking an acrosome, and both conditions show high rates of chromosomal abnormalities and DNA fragmentation compared to fertile men.
- - Genetic mutations in key genes have been identified as causes of both conditions, which is crucial for improving diagnosis and treatment options, especially since current fertility treatments like intracy
Hum Fertil (Camb)
June 2015
Article Synopsis
- This study investigates the meiotic segregation of sperm in men with sex chromosome mosaicism, specifically those with a 45,X cell line.
- Using fluorescence in situ hybridization (FISH) and DNA fragmentation tests, researchers found higher rates of abnormal sperm (XY disomy) in two out of three patients.
- However, the rates of DNA fragmentation in sperm were similar to those in a control group, and existing literature on this topic is limited, complicating comparisons across cases.
