Publications by authors named "Minh Hieu Ho"
Article Synopsis
- Current biofabrication methods struggle to mimic the complex relationships between the shapes and functions of engineered tissues due to limitations in hydrogels used.
- This study introduces a new microfluidics platform that allows for precise control over the structure and composition of hydrogels through a two-step process, enabling the creation of unique shapes, sizes, and stiffness patterns.
- The platform successfully encapsulates stem cells and demonstrates how variations in stiffness can influence cell behavior, with potential implications for breast cancer metastasis based on stiffness gradients.
The Efficacy of Silver-Based Electrospun Antimicrobial Dressing in Accelerating the Regeneration of Partial Thickness Burn Wounds Using a Porcine Model.
Polymers (Basel)
September 2021
(1) Background: Wounds with damages to the subcutaneous are difficult to regenerate because of the tissue damages and complications such as bacterial infection. (2) Methods: In this study, we created burn wounds on pigs and investigated the efficacy of three biomaterials: polycaprolactone-gelatin-silver membrane (PCLGelAg) and two commercial burn dressings, Aquacel Ag and UrgoTul silver sulfadiazine. In vitro long-term antibacterial property and in vivo wound healing performance were investigated.
View Article and Find Full Text PDFCharacterizations and Antibacterial Efficacy of Chitosan Oligomers Synthesized by Microwave-Assisted Hydrogen Peroxide Oxidative Depolymerization Method for Infectious Wound Applications.
Materials (Basel)
August 2021
The use of naturally occurring materials with antibacterial properties has gained a great interest in infected wound management. Despite being an abundant resource in Vietnam, chitosan and its derivatives have not yet been intensively explored for their potential in such application. Here, we utilized a local chitosan source to synthesize chitosan oligomers (OCS) using hydrogen peroxide (HO) oxidation under the microwave irradiation method.
View Article and Find Full Text PDFInvestigating the effect of multi-coated hydrogel layer on characteristics of electrospun PCL membrane coated with gelatin/silver nanoparticles for wound dressing application.
J Biomed Mater Res A
December 2021
In this study, the effect of coated hydrogel layer on characteristics of the whole gelatin/silver nanoparticles multi-coated polycaprolactone membrane (PCLGelAg) was investigated through systematic and typical wound dressing characterizations to select the optimal number of layers for practical applications. Scanning electron microscopy, free swell absorptive capacity and tensile test in both wet and dry conditions were conducted to characterize all fabricated membranes of six coating times. In vitro cytotoxicity and agar diffusion evaluation were also carried out to assess the biocompatibility and antibacterial activity of the membranes.
View Article and Find Full Text PDFArticle Synopsis
- This research focuses on creating and testing a new type of wound dressing made from an electrospun polycaprolactone (EsPCL) membrane enhanced with chitosan oligomers (COS) for better healing support.* -
- The study involved various experiments to assess the physical properties, antibacterial effectiveness, and compatibility of the membrane in both lab settings and in live mice models.* -
- Results indicated that higher concentrations of COS improved the membrane's thickness and antibacterial properties, promoted faster blood clotting, and positively influenced wound healing processes.*