Cafestol analogues from : inhibition and molecular docking to -glucosidase.

A new cafestol-type diterpenoid, 5-hydroxy-2-oxocafestol named coffecanepholide C () along with three known diterpenoids including cafestol , tricalysiolide A () and atractyligenin () were identified from the trunks collected at Lam Dong province, Vietnam. Their structures were elucidated by HRESIMS and NMR spectroscopic analysis (H, C, COSY, HSQC, HMBC, and NOESY NMR) as well as compared with data in the literature. Upon evaluation of the -glucosidase inhibitory activity, compound (IC = 142.

Two new -kaurane-type diterpene diastereomers isolated from .

Phytochemical investigation of the trunks of yielded two new kaurane diterpene diastereomers, which have been named coffecanepholide A, 3,16,17-trihydroxykauran-18-al () and coffecanepholide B, -3,16,17-trihydroxykauran-19-al (). Structural elucidation and configurational assignment were deduced from extensive spectroscopic NMR/HRESIMS analysis and by comparison with the spectral data of the literature relevant structures. The isolated compounds were assayed for inhibitory activities against -glucosidase.

A new oleanane-skeleton triterpene isolated from .

Extensive fractionation of -hexane extract from the dried powdered-trunks of Pierre ex A.Froehner (Rubiaceae) led to the isolation of a new oleanane-skeleton triterpene, coffecanolic acid (), along with three known analogues sumaresinolic acid (), oleanolic acid (), and 3--acetyloleanolic acid (). The chemical structures were elucidated using FT-IR, 1D and 2D NMR and HR-ESI-MS data analysis.