Publications by authors named "Mingzhu Su"
Background: This study delves into the complex interplay between genetics, 25-hydroxyvitamin D (25OHD), and schizophrenia (SCZ). It leverages extensive sample data derived from Genome-Wide Association Studies (GWAS) to uncover genetic correlations.
Methods: Employing Linkage Disequilibrium Score Regression (LDSC) and S-LDSC, this study investigates genetic connections between 25OHD and SCZ.
Background: Evidence of the association between sleep duration, depressive symptoms, and mortality in cancer survivors is limited.
Methods: 2,111 participants from the National Health and Nutrition Examination Surveys were involved and linked to a mortality database up to 31 December 2019. Sleep duration was self-reported at baseline.
Background: Multiple Sclerosis (MS), an autoimmune disorder causing demyelination and neurological damage, has been linked to 25-hydroxyvitamin D (25OHD) levels, suggesting its role in immune response and MS onset. This study used GWAS datasets to investigate genetic associations between 25OHD and MS.
Methods: We utilized a large-scale prospective cohort to evaluate serum 25OHD levels and MS risk.
Introduction: Frailty has a significant impact on the overall quality of life of older cancer survivors, but the relationships among frailty symptoms are not well understood. This study aims to explore the specific associations among multidimensional symptoms of frailty among older cancer survivors by employing network analysis to provide supportive evidence for targeted interventions in the future.
Materials And Methods: Data were obtained by cluster sampling from three large Grade-A tertiary hospitals in Shandong Province, China, and collected through face-to-face interviews by trained investigators.
Background: This study aimed to analyze the trends of Parkinson's disease (PD) mortality rates among Chinese residents from 2004 to 2021, provide evidence for the formulation of PD prevention and control strategies to improve the quality of life among PD residents.
Methods: Demographic and sociological data such as gender, urban or rural residency and age were obtained from the National Cause of Death Surveillance Dataset from 2004 to 2021. We then analyzed the trends of PD mortality rates by Joinpoint regression.
Purpose: This study aimed to describe the health-related quality of life (HRQoL) of cancer survivors in China by the five-level EuroQol-5-dimension (EQ-5D-5L) questionnaire and to explore the impact of the comorbidity of pre-existing chronic conditions on HRQoL in cancer survivors.
Methods: Data on cancer survivors were obtained from two cross-sectional surveys conducted in Shandong Province, China. The data of the Chinese general population, the Chinese diabetes population, the Chinese hypertension population, and the Chinese urban population from the published studies were used as the controls.
Introduction: Clinical observations have found that prolonged use of analgesics increases the incidence of infection. However, the direct causal relationship between prescription analgesic use (PAU) and risk of infection (ROI) remains unclear.
Methods: This study used Mendelian randomization (MR) design to estimate the causal effect of PAU on ROI, as well as their mediating factors.
In China, older cancer survivors may show heterogeneity in financial toxicity (FT). We aimed to identify FT profiles among older Chinese cancer survivors and examine the association between FT profiles and individual characteristics. We used a latent profile analysis to categorize participants and a multinomial logistic regression to examine the associations.
View Article and Find Full Text PDFAim: This study aimed to explore the relationship between typical dreams and the mental health of residents in village-in-city.
Methods: This study used the Chinese version of the Typical Dreams Questionnaire and Symptom Checklist 90 (SCL-90) to investigate the mental health status and typical dream themes of 1,190 residents recruited through random sampling from a village-in-city in Xi'an. Correlation analysis, -test, and binary regression analysis were performed on the data using SPSS 24.
Article Synopsis
- This study explores how frailty levels in older cancer survivors relate to financial hardships, aiming to understand this connection better.
- Out of 3,919 older cancer survivors, 40.3% were classified as robust, 35.9% as pre-frail, and 23.8% as frail, with frail individuals facing significantly more financial challenges across various domains.
- The findings stress the importance of recognizing frailty in cancer survivors to better address their financial needs and improve their overall well-being.
Article Synopsis
- The study focused on developing and validating a patient-reported outcome measure (PROM) to assess financial hardship among older cancer survivors in China, addressing a gap in research on this topic.* -
- The researchers created and refined the measure through qualitative interviews, expert consultations, and statistical methods, leading to a final version that consists of 10 relevant items.* -
- The final PROM, named HARDS, demonstrated strong reliability and validity, with a recommended cutoff score of 18.5 for predicting poor quality of life among participants.*
Ansamitocin P-3 (AP-3) is a promising anticancer agent. However, its low solubility has limited its biomedical applications. The preparation of liposomal formulations for the delivery of low solubility drugs using the microfluidic platform has attracted increasing attention in the pharmaceutical industry.
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- The study analyzed the levels of aerobic activity and strength training in older cancer survivors, focusing on their impact on psychological distress and sleep problems.
- Only 35.2% of participants met aerobic activity guidelines, with 12% engaging in strength training twice per week; many reported significant psychological distress and sleep issues.
- Higher levels of inactivity and insufficient activity were linked to worse mental health and sleep difficulties, while active survivors who strength trained frequently experienced more trouble staying asleep.
Background: Chinese clinical nurses are increasingly confronting patient death, as the proportion of hospital deaths is growing. Witnessing patient suffering and death is stressful, and failure to cope with this challenge may result in decreased well-being of nurses and impediment of the provision of "good death" care for patients and their families. To our knowledge, few studies have specifically explored clinical nurses' experiences coping with patient death in mainland China.
View Article and Find Full Text PDFBackground: There is limited information about the population characteristics and adverse health outcomes of older cancer patients in China. This study aimed to describe the prevalence of frailty and examine the association between frailty and health-related quality of life (HRQoL) among older cancer patients.
Methods: This was a cross-sectional study involving older patients diagnosed with cancer in two tertiary hospitals in Shandong Province, China.
Objective: Despite oncology providers' significant roles in patient care, few studies have been conducted to investigate oncology providers' understanding of financial toxicity. This study aimed to explore oncology providers' perceptions and practices relating to the financial toxicity of older cancer survivors in China.
Methods: A qualitative study was conducted.
Background: Hospital facilities in China are experiencing increased strain on existing systems and medical resources, necessitating the use of home-based hospice and palliative care (HBHPC). HBHPC primarily relies on community nurses and related medical personnel. Understanding the challenges that community nurses face when providing this form of care is urgently needed to optimize the design and delivery of HBHPC.
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- The study looked at how older cancer survivors in China deal with money problems after being diagnosed with cancer.
- Researchers interviewed 21 survivors and 20 family caregivers to understand their experiences.
- Key findings showed that these survivors often struggle with costs, rely on help from their children, and face stress that affects the whole family.
Background: Evidence is required to quantify the population-level effects of endoscopic screening for esophageal squamous cell carcinoma (ESCC). The objective of this study was to evaluate the long-term effectiveness of 1-time endoscopic ESCC screening in a Chinese rural population.
Methods: This community-based cohort study was based on an existing esophageal cancer screening program in Feicheng City, China.
Employment changes among Chinese family caregivers of long-term cancer survivors.
BMC Public Health
November 2020
Article Synopsis
- Family caregivers (FCGs) are important for taking care of long-term cancer survivors, but there aren't many studies on how this affects their jobs.
- In this study with 1,155 cancer survivors, researchers looked at how caregiving changed the work hours of FCGs during and after cancer treatment.
- They found that many FCGs reduced their work hours or stopped working, especially if the cancer survivors had serious health issues or were getting chemotherapy.
Objectives: High retention rates among direct care workers (DCWs) affect the quality of aged care. However, limited research has explored factors associated with retention in China's aged care industry. This study compared turnover intention among DCWs in Chinese hospitals and long-term care facilities (LTCFs).
View Article and Find Full Text PDFBackground: The purpose of this study was to estimate the proportion of Chinese cancer survivors experiencing financial hardship and then examine the relationship between material and behavioral financial hardship.
Methods: This study surveyed 964 cancer survivors who were 30 to 64 years old and 644 survivors who were 65 years old or older during 2015-2016 (1608 survivors in all). Material financial hardship was measured by whether they had borrowed money because of cancer, its treatment, or the lasting effects of treatment, and behavioral financial hardship was measured by whether they had forgone some cancer-related medical care because of cost.
Background: The present study aimed to first describe the work-related outcomes of cancer survivors and to then identify those characteristics that influenced the decision to stop working in rural China.
Methods: We assessed 752 cancer survivors (residents of rural areas, working at the time of diagnosis, >1 year since completing treatment) from the cross-sectional study "China Survey of Experiences with Cancer". Participants reported changes in employment status, income, and the ability to perform physical jobs due to cancer, as well as the work-related outcomes of their informal caregivers.