Publications by authors named "Mingzhong Yu"
The Impact of SGLT1 Inhibition on Frailty and Sarcopenia: A Mediation Mendelian Randomization Study.
J Cachexia Sarcopenia Muscle
December 2024
Article Synopsis
- The study explored the effect of inhibiting SGLT1 on frailty and sarcopenia in older adults, aiming to understand its potential benefits.
- A two-sample Mendelian randomization analysis showed that SGLT1 inhibition led to a decrease in frailty index and a lower risk of weak grip strength in individuals aged 60 and over.
- Findings identified insulin resistance and various proteins and metabolites as mediators, suggesting that targeting SGLT1 could be a promising therapeutic approach for improving health in older adults.
Metabolic syndrome (MetS) is closely related to cardiovascular and cerebrovascular diseases, and genetic predisposition is one of the main triggers for its development. To identify the susceptibility genes for MetS, we investigated the relationship between angiotensin-converting enzyme 2 (ACE2) single nucleotide polymorphisms (SNPs) and MetS in southern China. In total, 339 MetS patients and 398 non-MetS hospitalized patients were recruited.
View Article and Find Full Text PDFObjective: Diabetes is an important risk factor for sarcopenia and contributes to poor prognosis; it is important for clinicians to identify sarcopenia early in the population with type 2 diabetes mellitus. Our aim was to establish a clinical screening model of sarcopenia in Chinese patients with type 2 diabetes mellitus.
Methods: A cross-sectional study was conducted involving 1131 hospitalized patients (62.
Apelin-APJ system has been implicated in the regulation of metabolic homeostasis. This study aimed to explore the genetic predisposition of the apelin-APJ system to metabolic syndrome. 1005 subjects were enrolled, including 448 metabolic syndrome patients and 557 controls.
View Article and Find Full Text PDF