Sphingosine-1-phosphate in the regulation of diabetes mellitus: a scientometric study to an in-depth review.

Diabetes is a significant global health issue, causing extensive morbidity and mortality, and represents a serious threat to human health. Recently, the bioactive lipid molecule Sphingosine-1-Phosphate has garnered considerable attention in the field of diabetes research. The aim of this study is to comprehensively understand the mechanisms by which Sphingosine-1-Phosphate regulates diabetes.

Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review.

Background: Medicinal and food homologous plants (MFHPs) which can improve Type 2 Diabetes Mellitus (T2DM) draw significant attention among the public due to their low toxicity and more safety. Polysaccharides, one of the various active components of MFHPs, are recognized as effective modulators of the intestinal flora. By altering the composition of intestinal flora and affecting their metabolic products, polysaccharides can improve T2DM, making them a central focus of anti-diabetic research.

Retarded astrogliogenesis in response to hypoxia is facilitated by downregulation of CIRBP.

The adverse impacts of chronic hypoxia on maternal and infant health at high altitudes warrant significant attention. However, effective protective measures against the resultant growth restrictions and neurodevelopmental disorders in infants and young children are still lacking. This study investigated the neurodevelopment of mice offspring under hypoxic conditions by exposing pregnant mice to a hypobaric oxygen chamber that simulated the hypobaric hypoxia at an altitude of 4000 m until 28 days after delivery.

Fluorinated MOF-Based Hexafluoropropylene Nanotrap for Highly Efficient Purification of Octafluoropropane Electronic Specialty Gas.

High-purity octafluoropropane (CF) electronic specialty gas is a key chemical raw material in semiconductor and integrated circuit manufacturing industry, while selective removal of hexafluoropropylene (CF) impurity for CF purification is essential but a challenging task. Here we report a fluorinated cage-like MOF Zn-bzc-CF (bzc=5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid) for CF/CF separation. The incorporation of -CF groups not only provides suitable pore aperture size for highly efficient size-exclusive CF/CF separation, but also creates hydrophobic microenvironments, endowing Zn-bz-CF high chemical stability.

Defective metal-organic framework derived from the waste plastic bottles for rapid and efficient nitroimidazole antibiotics removal.

In order to alleviate the pressure on the ecological environment and human health caused by wastewater of nitroimidazole antibiotics and poly(ethylene terephthalate) (PET) plastic waste, we propose a strategy of using defective MIL-68(Al) (d-MIL-68(Al)) derived from waste PET plastic for dimetridazole (DMZ) capture. The resulting d-MIL-68(Al) exhibits an excellent adsorption capacity of 555.6 mg g, which is three times of pristine MIL-68(Al) (181.

Combined Skeleton and Spatial Rigidification of AIEgens in 2D Covalent Organic Frameworks for Boosted Fluorescence Emission and Sensing of Antibiotics.

AIEgens show relatively weak fluorescence performance owing to the existence of π-π interlayer accumulation, molecular layer planarization, and intramolecular rotation in aggregation-induced emission (AIE) molecules, which limit its application scope. Herein, we put forward a combined skeleton and spatial rigidification method to boost the fluorescence emission efficiency of AIEgens. As a proof-of-concept experiment, two highly fluorescent covalent organic frameworks (COFs) were designed and constructed by the Knoevenagel condensation reaction.