Publications by authors named "Mingze Zeng"

Wound healing faces challenges like inflammation, infection, and limited monitoring capabilities, and traditional dressings often lack the ability to promote healing or provide real-time wound status updates. Early pro-inflammatory responses help clear pathogens and damaged tissue, while timely anti-inflammatory modulation aids tissue regeneration, making sequential inflammation regulation crucial. Additionally, wound temperature, a key infection biomarker, enables real-time monitoring for effective management.

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  • Investigating brain neural circuits is crucial for improving diagnosis and treatment of neurodegenerative diseases, but traditional metal electrodes have issues like mechanical mismatches and poor resolution.
  • All-hydrogel neural electrodes with multi-electrode arrays aim to resolve these issues but have struggled with conductivity and bonding stability.
  • The new four-layer all-hydrogel electrode shows significantly improved conductivity and bonding, allowing for better recording of neural activity, thus enhancing research on neurodegenerative conditions.
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Inspired by the strong light absorption of carbon nanotubes, we propose a fabrication approach involving one-dimensional TiO/BiS QDs nanotubes (TBNTs) with visible red-light excitable photoelectric properties. By integrating the construction of heterojunctions, quantum confinement effects, and morphological modifications, the photocurrent reached 9.22 µA/cm which is 66 times greater than that of TiO nanotubes (TNTs).

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  • High-precision neural recording is crucial for understanding how the nervous system communicates, leading to a push for better implantable microelectrode arrays (MEAs).
  • The research introduces a new MEA substrate using silk fibroin that is flexible, biocompatible, and minimizes mechanical mismatch with tissues, alongside a novel method to enhance conductivity and reduce impedance.
  • Experimental results show the silk-based MEAs have excellent capabilities for recording weak neural signals, highlighted by the ability to detect action potentials, which could advance our understanding of neural circuits.
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Nerve injuries and neurological diseases remain intractable clinical challenges. Despite the advantages of stem cell therapy in treating neurological disorders, uncontrollable cell fates and loss of cell function are still challenging. Recently, increasing attention has been given to the roles of external physical signals, such as electricity and ultrasound, in regulating stem cell fate as well as activating or inhibiting neuronal activity, which provides new insights for the treatment of neurological disorders.

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As one of the physical stimulus tools to target neuromodulation-related biological entities, mild thermal stimulus has attracted increasing attention in unraveling neural differentiation processing. However, thermal stimulus for neural behavior regulation has been relatively unexplored due to the challenge in finding a good method of exerting thermal stimulus. Considering the distance-dependent temperature preservation efficiency and the native importance of a bioactive matrix, we herein put forward the design of a photothermal hydrogel by immobilizing photothermal dopamine (DA) in hyaluronic acid (HA) chains.

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As nanozymes, carbon dots (CDs) have attracted increasing attention due to their remarkable properties. Besides general enzyme activity, their photoluminescence and photothermal properties have been explored rarely, whereas their synergistic effects might produce CDs-based nanozymes of high performance. Here, iron-doped CDs (Fe-CDs) with tunable fluorescence and enhanced peroxidase-like activity were designed to develop a novel "three-in-one" multifunctional platform to provide dual-mode/dual-target detection and near infrared (NIR)-assisted antibacterial ability.

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Wound management is highly clinically desirable due to the complexity and diversity of the wound repair process. However, it is still a major clinical challenge to develop a wound dressing with the capabilities of real-time and remote monitoring during wound healing. Herein, we have designed a polymer-based wound dressing in the form of a conductive, soft, temperature-responsive, antibacterial and biocompatible hydrogel, which is composed of polyacrylic acid (PAA)-grafted poly(-isopropylacrylamide) (PNIPAM), vinyl-based polyacrylamide (PAM) and silver nanowires (AgNWs).

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With wide clinical demands, therapies for traumatic brain injury (TBI) are far from satisfactory. Combining the merits of stem cells but avoiding the risk of immunologic rejection, bone marrow mesenchymal stem cell-derived exosomes (BME) attract increasing interests and have been proved effective for TBI repair by intravenous or in situ injection. However, difficulties in sustained delivery or aggregation in lesion sites remain obstacle to using BME for TBI.

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  • Conductive hydrogel (CH) is gaining traction in bioelectronics due to its flexibility, but integrating biocompatibility and electrical performance remains a challenge.
  • Hyaluronic acid (HA) combined with dopamine (DA)-modified PEDOT:PSS creates a new type of hydrogel (HA-DA-PP) that improves conductivity and stretchability with a stable, homogeneous structure.
  • The resulting HA-DA-PP hydrogel exhibits impressive stretchability (over 470%) and sensitivity for monitoring human movement and biological signals, showcasing a novel approach for high-performance bioelectronic applications.
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Delivering electrical signals to neural cells and tissue has attracted increasing attention in the treatment of nerve injuries. Unlike traditional wired electrical stimulation, wireless and remote light stimulation provides less invasive and longer-lasting interfaces, holding great promise in the treatment of nerve injuries and neurodegenerative diseases, as well as human-computer interaction. Additionally, a bioactive matrix that bridges the injured gap and induces nerve regeneration is essential for injured nerve repair.

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