Marine Organisms as a Prolific Source of Bioactive Depsipeptides.

Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and amino acids linked together by amide and ester bonds, have potential applications in agriculture and medicine. A growing body of evidence demonstrates that marine organisms are prolific sources of depsipeptides, such as marine cyanobacteria, sponges, mollusks, microorganisms and algae. However, these substances have not yet been comprehensively summarized.

Whole-Genome Sequence Analysis of an Endophytic Fungus sp. SPS-2 and Its Biosynthetic Potential of Bioactive Secondary Metabolites.

As one of the commonly isolated endophytic fungi, has been known for the production of numerous secondary metabolites (SMs). However, its detailed genomic features and SM biosynthetic potential have not been extensively studied thus far. The present work focuses on the whole-genome sequencing and assembly of an endophytic strain sp.

: A Prolific Source of Bioactive Secondary Metabolites with Therapeutic Potential.

, one of the most important actinomycetes genera, is well-known as the treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth genomic analysis of the reported strains, all SMs from this genus are comprehensively summarized, containing structural features, bioactive properties, and mode of actions as well as their biosynthetic and chemical synthesis pathways. The perspective enables a detailed view of -derived SMs, which will enrich the chemical diversity of natural products and inspire new drug discovery in the pharmaceutical industry.