Continuous Evolution of Eu/Eu Mixed Valency Driven by Pressure and Temperature.

Continuous mixed valency involving Eu and Eu in EuBiSe can be induced under applied pressure or at reduced temperatures. The monoclinic structure of EuBiSe, crystallizing in the 2/ space group (No. 11), features linear chains of Eu atoms aligned along the -axis.

Anterior Cingulate Cortex-Anterior Insular Cortex Circuit Mediates Hyperalgesia in Adolescent Mice Experiencing Early Life Stress.

Understanding neurobiological mechanisms underlying changes in behavior and neural activity caused by early life stress (ELS) is essential for improving these adverse outcomes in individuals. ELS incited by exposure to maternal separation (MS) can be defined as a form of social pain, but little is known about the neural mechanism in adolescents with ELS-induced pain sensitization. Employing an MS-induced ELS paradigm in mice, we reported here that both male and female MS mice aged 1-2 months exhibited mechanical and thermal hyperalgesia using paw-withdrawal and hot/cold plate tests.

Supramolecular Engineering of Nanoceria for Management and Amelioration of Age-Related Macular Degeneration via the Two-Level Blocking of Oxidative Stress and Inflammation.

Age-related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the global leading cause of irreversible blindness. Current first-line therapeutics, vascular endothelial growth factor (VEGF) antagonists, often yield incomplete and suboptimal vision improvement, necessitating the exploration of novel and efficacious therapeutic approaches. Herein, a supramolecular engineering strategy to construct moringin (MOR) loaded α-cyclodextrin (α-CD) coated nanoceria (M@CCNP) is constructed, where the hydroxy and newly formed carbonyl groups of α-CD interact with the nanoceria surface via O─Ce conjunction and the isothiocyanate group of MOR inserts deeply into the α-CD cavity via host-guest interaction.

A nomogram to distinguish noncardiac chest pain based on cardiopulmonary exercise testing in cardiology clinic.

Background: Psychological disorders, such as anxiety and depression, are considered to be one of the causes of noncardiac chest pain (NCCP). And these patients can be challenging to differentiate from coronary artery disease (CAD), leading to a considerable number of patients still undergoing angiography. We aim to develop a practical prediction model and nomogram using cardiopulmonary exercise testing (CPET), to help identify these patients.

Polymorphism of Pb(PO)OH within the LK-99 mixture.

During the synthetic exploration targeting the polycrystalline compound LK-99, an unexpected phase, Pb(PO)OH, was identified as a byproduct. We elucidated the composition of this compound through single-crystal X-ray diffraction analysis. Subsequent synthesis of the target compounds was achieved via high-temperature solid-state pellet reactions.

Giant Uniaxial Magnetocrystalline Anisotropy in SmCrGe.

Magnetic anisotropy is a crucial characteristic for enhancing the spintronic device performance. The synthesis of SmCrGe single crystals through a high-temperature solution method has led to the determination of uniaxial magnetocrystalline anisotropy. Phase verification was achieved by using scanning transmission electron microscopy (STEM), powder, and single-crystal X-ray diffraction techniques.

UNeXt: An Efficient Network for the Semantic Segmentation of High-Resolution Remote Sensing Images.

The application of deep neural networks for the semantic segmentation of remote sensing images is a significant research area within the field of the intelligent interpretation of remote sensing data. The semantic segmentation of remote sensing images holds great practical value in urban planning, disaster assessment, the estimation of carbon sinks, and other related fields. With the continuous advancement of remote sensing technology, the spatial resolution of remote sensing images is gradually increasing.

NDUFS3 alleviates oxidative stress and ferroptosis in sepsis induced acute kidney injury through AMPK pathway.

In recent years, ferroptosis has been found to play an important role in various acute kidney injury (AKI). However, relatively little research has been conducted on sepsis-induced acute kidney injury (SI-AKI). As an important trigger of ferroptosis, how mitochondrial damage plays a regulatory role in SI-AKI is still unclear.

Transient Consciousness Disorder During Emergency Cesarean Section in Patients with Labor Analgesia.

A patient who was 39 weeks pregnant was admitted to the hospital to be expecting labor and performed labor analgesia when the uterine orifice was opened to 2 cm. We successfully performed L2.3 epidural puncture in the lumbar space and equipped her with a self-controlled epidural analgesia infusion pump (100mL, 10mL 1% ropivacaine + 50ug sufentanil + 89mL normal saline) with a load of 8mL for continuous delivery.

Enhancement of Brillouin nonlinearities with a coupled resonator optical waveguide.

Stimulated Brillouin scattering (SBS) is a nonlinear optical phenomenon mediated from the coupling of photons and phonons. It has found applications in various realms, yet the acousto-optic interaction strength remains relatively weak. Enhancing the SBS with resonant structures could be a promising solution, but this method faces strict constraints in operational bandwidth.

Objective Ischemia, Subjective Angina, and Psychological Distress in Angina With No Obstructive Coronary Disease.

Background: Angina with no obstructive coronary disease (ANOCA) and ischemia with no obstructive coronary disease, prevalent yet underrecognized conditions, mostly affect women. Previous studies rarely distinguished between them. We aimed to compare the prevalence of objective ischemia through various examinations in women with ANOCA and assess the impact of objective and subjective ischemia on their mental health.

A Comprehensive Assessment of the Chinese Version of the Duke Activity Status Index in Patients with Cardiovascular Diseases.

Background: Exercise capacity serves as a direct representation of cardiac function. The Duke Activity Status Index (DASI), a self-administered 12-item questionnaire, covers aspects of daily living, household tasks, sexual function, and physical activity. Although widely used to evaluate exercise capacity, its validation in Chinese cardiovascular disease (CVD) patients has not been thoroughly explored.

An AS-OCT image dataset for deep learning-enabled segmentation and 3D reconstruction for keratitis.

Infectious keratitis is among the major causes of global blindness. Anterior segment optical coherence tomography (AS-OCT) images allow the characterizing of cross-sectional structures in the cornea with keratitis thus revealing the severity of inflammation, and can also provide 360-degree information on anterior chambers. The development of image analysis methods for such cases, particularly deep learning methods, requires a large number of annotated images, but to date, there is no such open-access AS-OCT image repository.

C176-loaded and phosphatidylserine-modified nanoparticles treat retinal neovascularization by promoting M2 macrophage polarization.

Retinal neovascularization (RNV), a typical pathological manifestation involved in most neovascular diseases, causes retinal detachment, vision loss, and ultimately irreversible blindness. Repeated intravitreal injections of anti-VEGF drugs were developed against RNV, with limitations of incomplete responses and adverse effects. Therefore, a new treatment with a better curative effect and more prolonged dosage is demanding.

Anti-resonant acoustic waveguides enabled tailorable Brillouin scattering on chip.

Empowering independent control of optical and acoustic modes and enhancing the photon-phonon interaction, integrated photonics boosts the advancements of on-chip stimulated Brillouin scattering (SBS). However, achieving acoustic waveguides with low loss, tailorability, and easy fabrication remains a challenge. Here, inspired by the optical anti-resonance in hollow-core fibers and acoustic anti-resonance in cylindrical waveguides, we propose suspended anti-resonant acoustic waveguides (SARAWs) with superior confinement and high selectivity of acoustic modes, supporting both forward and backward SBS on chip.

Barriers and facilitators to implementing a Canadian shared-care ADHD program in pediatric settings in Shanghai: a consolidated framework for implementation research approach.

Objectives: The vast majority of children with Attention-Deficit Hyperactivity Disorder (ADHD) do not have access to proper diagnosis and treatment in China. The goal of this project is to identify the challenges and facilitators in implementing a Canadian ADHD Shared Care Pathways program in pediatric settings in Shanghai region.

Methods: Purposive semi-structured focus groups were conducted on a total of 13 healthcare practitioners from the Shanghai Xinuha, Ninghai and Chongming hospitals.

Slow-light-enhanced Brillouin scattering with integrated Bragg grating.

Advancements in photonic integration technology have enabled the effective excitation of simulated Brillouin scattering (SBS) on a single chip, boosting Brillouin-based applications such as microwave photonic signal processing, narrow-linewidth lasers, and optical sensing. However, on-chip circuits still require large pump power and centimeter-scale waveguide length to achieve a considerable Brillouin gain, making them both power-inefficient and challenging for integration. Here, we exploit the slow-light effect to significantly enhance SBS, presenting the first, to the best of our knowledge, demonstration of a slow-light Brillouin-active waveguide on the silicon-on-insulator (SOI) platform.

Loading-effect-based three-dimensional microfabrication empowers on-chip Brillouin optomechanics.

The acousto-optic interaction known as stimulated Brillouin scattering (SBS) has emerged as a fundamental principle for realizing crucial components and functionalities in integrated photonics. However, the main challenge of integrating Brillouin devices is how to effectively confine both optical and acoustic waves. Apart from that, the manufacturing processes for these devices need to be compatible with standard fabrication platforms and streamlined to facilitate their large-scale integration.