Stimuli-Controlled Keto-Enol Tautomerism of Extended Unsaturated Carbonyls for Gating Photoswitching of Diarylethenes.

Gated photoswitching systems, which enable control over photochromic properties, play an important role in chemistry. Here, we present a novel gated system based on extended unsaturated 1,3-dicarbonyl derivatives of diarylethenes by manipulating keto-enol tautomerism. While the intramolecular charge transfer process blocked the photochromism, the creation of an ester enabled efficient bidirectional photoswitching.

Spatial joint hazard assessment of landslide susceptibility and intensity within a single framework: Environmental insights from the Wenchuan earthquake.

To comprehensively assess regional landslide hazards, we propose a geospatial approach that jointly evaluates both the probability of occurrence (susceptibility) and potential destructive power (intensity) within a single framework, overcoming the limitations of previous studies that treated these two disaster scenarios independently. Focusing on the largest landslide event triggered by the Wenchuan earthquake in China, we collected landslide occurrence and count data at the slope unit level, alongside 18 environmental factors, including seismic data. To enable this multi-hazard single-framework evaluation, we employed two Bayesian spatial joint regressions: the spatial shared component model (SSCM) and the spatial shared hyperparameter model (SSHM).

Feasibility Study on Optimising the Efficacy of a Population Age Estimation Model for South China by Combined Machine Learning for the Second and Third Molars.

Dental age estimation, as an important part of forensic anthropology, has a wide range of applications for its results in legal practice. Given the lowered legal age for criminal responsibility in China and the increasing juvenile delinquency, we establish a morphological database targeting the second (M2) and third molars (M3) of the Southern Chinese population. Full mouth orthopantomography from 1486 individuals aged 8.

Cancer-Associated Fibroblast-Derived FGF7 Promotes Clear Cell Renal Cell Carcinoma Progression and Macrophage Infiltration.

As the predominant stromal cells in the ccRCC surrounding environment, cancer-associated fibroblasts (CAFs) have been established as supportive of tumor growth. However, the detailed molecular mechanisms underlying the supporting role of CAFs in ccRCC have not been well characterized. Evidence from the clustering consensus analysis, single-cell analysis, and the experimental results illustrate that CAF-derived FGF7 plays a crucial role as a signaling mediator between CAFs and ccRCC tumor cells.

Benefit evaluation of sloping land conversion program in the upper reaches of the Yellow River.

This study used forestry statistical data and field survey data from 2000 to 2018 to analyze the ecological restoration effect of the returning farmland to forest project in the upper reaches of the Yellow River, considering four perspectives, namely, project construction goals, ecosystem quality, ecosystem service functions, and ecological restoration driving factors. One-way ANOVA and logit regression analysis methods were used for comparison. The results show that the implementation of the Grain for Green Project has reduced the carrying capacity of rural land, effectively curbed the continuous deterioration of the ecological environment, and protected and benefited the forest ecosystem.

Exploring heat shock proteins as therapeutic targets for Parkinson's disease.

Parkinson's disease (PD) is characterized by the accumulation of misfolded α-synuclein (α-syn). Promoting the degradation of misfolded proteins has been shown to be an effective approach to alleviate PD. This review highlights the roles of specific heat shock proteins (HSPs) in modulating α-syn aggregation and neuronal survival.

Air pollution's numerical, spatial, and temporal heterogeneous impacts on childhood hand, foot and mouth disease: a multi-model county-level study from China.

Background: While stationary links between childhood hand, foot and mouth disease (HFMD) and air pollution are known, a comprehensive study on their heterogeneous relationships (nonstationarity), jointly considering numerical, temporal and spatial dimensions, has not been reported.

Methods: Monthly HFMD incidence and air pollution data were collected at the county level from Sichuan-Chongqing, China (2009-2011), alongside meteorological and social environmental covariates. Key influential factors were identified using random forest (RF) under the stationary assumption.

Identifying cooperating cancer driver genes in individual patients through hypergraph random walk.

Objective: Identifying cancer driver genes, especially rare or patient-specific cancer driver genes, is a primary goal in cancer therapy. Although researchers have proposed some methods to tackle this problem, these methods mostly identify cancer driver genes at single gene level, overlooking the cooperative relationship among cancer driver genes. Identifying cooperating cancer driver genes in individual patients is pivotal for understanding cancer etiology and advancing the development of personalized therapies.

Synchronous small cell neuroendocrine carcinoma of the cervix and immature ovarian teratoma: A case report and literature review.

The onset of two synchronous primary malignancies of the female genital tract is uncommon; therefore, the simultaneous occurrence of cervical small cell neuroendocrine carcinoma and ovarian immature teratoma is rare. The present study describes the case of a woman with cervical small cell neuroendocrine carcinoma complicated by ovarian immature teratoma. The clinical manifestations, and the histopathological and immunophenotypic features of the patient are recorded.

Long non-coding RNA JPX promotes endometrial carcinoma progression via janus kinase 2/signal transducer and activator of transcription 3.

Introduction: Although LncRNA JPX has been linked to a number of malignancies, it is yet unknown how it relates to endometrial carcinoma (EC). Investigating the expression, functional activities, and underlying molecular processes of lncRNA JPX in EC was the goal of this work.

Methods: RT-qPCR was used to examine the differences in lncRNA/microRNA (miRNA, miR)/mRNA expression between normal cervical and EC tissues or cells.

Revealing spatiotemporal inequalities, hotspots, and determinants in healthcare resource distribution: insights from hospital beds panel data in 2308 Chinese counties.

Background: Ensuring universal health coverage and equitable access to health services requires a comprehensive understanding of spatiotemporal heterogeneity in healthcare resources, especially in small areas. The absence of a structured spatiotemporal evaluation framework in existing studies inspired us to propose a conceptual framework encompassing three perspectives: spatiotemporal inequalities, hotspots, and determinants.

Methods: To demonstrate our three-perspective conceptual framework, we employed three state-of-the-art methods and analyzed 10 years' worth of Chinese county-level hospital bed data.

PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway.

Endometrioid adenocarcinoma (EEC) is one of the most common cancers of the female reproductive system. In recent years, much emphasis has been placed on early diagnosis and treatment. PAX2 (Paired box 2) inactivation is reportedly an important biomarker for endometrioid intraepithelial neoplasia (EIN) and EEC.

Case Report: A variant resulting in autoinflammatory disease in a Chinese newborn.

Background: Cryopyrin-associated periodic syndromes (CAPS) have been considered autoinflammatory diseases resulting from gene mutations. In recent years, these conditions have been redefined as -associated autoinflammatory diseases (-AID). Our previous study highlighted a case of a Chinese individual carrying the mutation.

PhenoDriver: interpretable framework for studying personalized phenotype-associated driver genes in breast cancer.

Identifying personalized cancer driver genes and further revealing their oncogenic mechanisms is critical for understanding the mechanisms of cell transformation and aiding clinical diagnosis. Almost all existing methods primarily focus on identifying driver genes at the cohort or individual level but fail to further uncover their underlying oncogenic mechanisms. To fill this gap, we present an interpretable framework, PhenoDriver, to identify personalized cancer driver genes, elucidate their roles in cancer development and uncover the association between driver genes and clinical phenotypic alterations.

Elastic, Piezoelectric Coefficients, and Internal Frictions of a Single Alpha-Quartz Crystal Determined by Partial-Electrode Electromechanical Impedance Spectroscopy.

In this work, all independent elastic coefficients, piezoelectric coefficients, and internal frictions of a single alpha-quartz crystal are determined at room temperature using our recently proposed partial-electrode electromechanical impedance spectroscopy (PE-EMIS). In PE-EMIS, the rectangular parallelepiped quartz sample with two small partial electrodes fabricated on a corner is self-excited/sensed. The conductance spectrum (equivalent to the acoustic resonance spectrum) measured by an impedance analyzer under a free boundary condition is noiseless, allowing the first 100 eigenmodes ranging from 50 to 310 kHz to be accurately fit.

Different and unified responses of soil bacterial and fungal community composition and predicted functional potential to 3 years' drought stress in a semiarid alpine grassland.

Introduction: Soil microbial communities are key to functional processes in terrestrial ecosystems, and they serve as an important indicator of grasslands status. However, the responses of soil microbial communities and functional potential to drought stress in semiarid alpine grasslands remain unclear.

Methods: Here, a field experiment was conducted under ambient precipitation as a control, -20% and -40% of precipitation to explore the responses of soil microbial diversity, community composition, and predicted functional potential to drought stress in a semiarid alpine grassland located in the northwest of China.

A novel heterophilic graph diffusion convolutional network for identifying cancer driver genes.

Identifying cancer driver genes plays a curial role in the development of precision oncology and cancer therapeutics. Although a plethora of methods have been developed to tackle this problem, the complex cancer mechanisms and intricate interactions between genes still make the identification of cancer driver genes challenging. In this work, we propose a novel machine learning method of heterophilic graph diffusion convolutional networks (called HGDCs) to boost cancer-driver gene identification.

CIN grades possessing different HPV RNA location patterns and RNAscope is helpful tool for distinguishing squamous intraepithelial lesions in difficult cervical cases.

Background And Objectives: The precise grading and characterization of cervical intraepithelial neoplasia (CIN) has been the focus of pathologists for a long time. This study aimed to explore known strategies for the grading of CINs.

Methods: After routine H&E review, 85 lesions graded CIN 1, 2, or 3 were investigated primarily by HPV RNAscope to detect HR-HPV and LR-HPV, in combination with an HPV-DNA test and P16/Ki67 immunohistochemistry (IHC).

Responses of terrestrial ecosystem productivity and community structure to intra-annual precipitation patterns: A meta-analysis.

Introduction: The productivity and community structures of terrestrial ecosystems are regulated by total precipitation amount and intra-annual precipitation patterns, which have been altered by climate change. The timing and sizes of precipitation events are the two key factors of intra-annual precipitation patterns and potentially drive ecosystem function by influencing soil moisture. However, the generalizable patterns of how intra-annual precipitation patterns affect the productivity and community structures of ecosystems remain unclear.

Gentamicin promoted the production of CD4CD25 Tregs via the STAT5 signaling pathway in mice sepsis.

Background: Increasing studies have reported that gentamicin (GNT) plays an essential role in sepsis; however, its underlying mechanism is still unclear. In this study, we investigated the mechanism of GNT in sepsis.

Results: We observed that GNT enhanced survival and alleviated inflammatory injuries of the lungs, liver, kidneys, and intestines in mice with sepsis.

Determining Full Matrix Constants of Piezoelectric Crystal From a Single Sample Using Partial Electrode Electromechanical Impedance Spectroscopy.

To determine all the material constants of a piezoelectric crystal using the IEEE resonance method or ultrasonic method, several samples with specific geometries and orientations are required, and the obtained results may be somewhat self-contradictory. The resonant ultrasound spectroscopy (RUS) can determine full material constants of a single piezoelectric sample by matching the numerically computed eigenfrequencies to the measured resonance spectrum. However, typically the usage of PZT transducers for excitation and reception makes the testing complicated and may add additional mass and damping.

Spatiotemporal disparities in regional public risk perception of COVID-19 using Bayesian Spatiotemporally Varying Coefficients (STVC) series models across Chinese cities.

Regional public attention has been critical during the COVID-19 pandemic, impacting the effectiveness of sub-national non-pharmaceutical interventions. While studies have focused on public attention at the national level, sub-national public attention has not been well investigated. Understanding sub-national public attention can aid local governments in designing regional scientific guidelines, especially in large countries with substantial spatiotemporal disparities in the spread of infections.

Nonlinear electromechanical impedance spectroscopy: A powerful tool for studying amplitude dependent internal frictions of solids.

Strain amplitude dependent effects of materials/structures are very important in the field of material science and engineering and have been found to be extremely sensitive to defects or damage. In this work, a nonlinear electromechanical impedance spectroscopy (N-EMIS) technique is proposed to characterize the amplitude dependent internal frictions (ADIFs) and modulus defects (or resonance shift) of materials. First, a new experimental scheme called the on/off parallel resistor capacitor circuit is proposed to measure the N-EMIS of a piezoelectric transducer (PZT)-specimen composite system under high driving levels.

A novel nonsense mutation in the TCOF1 gene in one Chinese newborn with Treacher Collins syndrome.

Objective: The purpose of this study is that analyze the clinical characters of Treacher Collins syndrome (TCS) with the de nove TCOF1 mutation and emphasize the genetic research result.

Methods: Genomic DNA from the proband and his parents were extracted from 200 to 400 μl of peripheral blood samples. A 4000 pathgenic genes diagnostic screening panel developed by our laboratory group was used for gene mutation screening.