Publications by authors named "Mingyu Li"

Pancharatnam-Berry (PB) phase modulation leverages the precise linear correspondence between output phase and nanopillar rotation angle, enabling wide application in modulating focal spherical waves. However, the intrinsic material absorption of waveguide structure inevitably brings energy loss within the visible light spectral range, severely limiting focusing efficiency over broad bandwidths under general models of nanopillars. Here, we introduce a dual-coupled metalens composed of an air slot-etched rectangular TiO nanopillar, and the extremely narrow air gap along its long axis of nanopillar can be regarded as a high-aspect-ratio rectangular waveguide for strictly confining the incident light.

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Climate change has exposed desert ecosystems to frequent extreme disturbances, including wet-dry cycles and freeze-thaw events, which accelerate desertification on a global scale. The limited nutrient availability characteristic of these ecosystems may constrain microbial survival and growth, making them more vulnerable to environmental perturbations and stressors. However, how nutrient availability modulates the stability of soil ecological communities and functions in desert ecosystems remains poorly understood.

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Blockade of the glucagon receptor (GCGR) has been shown to improve glycemic control. However, this therapeutic approach also brings side effects, such as α-cell hyperplasia and hyperglucagonemia, and the mechanisms underlying these side effects remain elusive. Here, we conduct single-cell transcriptomic sequencing of islets from male GCGR knockout (GCGR-KO) mice.

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Wet etching is the mainstream fabrication method for single-bar quantum cascade lasers (QCLs). Different etching solutions result in varying etching effects on III-V semiconductor materials. In this study, an efficient and nearly ideal etching solution ratio was proposed for simultaneously etching both InP and GaInAs/AlInAs, and the surface chemical reactions induced by each component of the etching solution during the process were investigated.

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This study investigated the influence of natural lotus seed starch on the adsorption of seven endogenous phenolic acids present in lotus seeds. The research delineated the interaction mechanisms and subsequently analyzed the alterations in starch characteristics following adsorption. A comprehensive suite of analytical techniques, including adsorption isotherms, C NMR, DSC, LF-NMR, rheology, particle size, and potential analyses was employed.

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In traditional Chinese medicine, the root bark and leaves of are utilized to treat dysentery, parasitic infections, and digestive disorders. In this study, the n-butanol extract of (NBA) exhibited potent antioxidant properties, protecting HaCaT cells from UVB-induced damage, and was abundant in phenolic and flavonoid compounds. Using UPLC-QTOF-MS analysis, several antioxidants within NBA were identified.

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Introduction: During influenza season, some patients tend to seek medical advice through online platforms. However, due to time constraints, the informational and emotional support provided by physicians is limited. Large language models (LLMs) can rapidly provide medical knowledge and empathy, but their capacity for providing informational support to patients with influenza and assisting physicians in providing emotional support is unclear.

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Background/objectives: Stroke represents the primary cause of death and persistent disability globally, leading to around 5.5 million annual patient fatalities. The objective was to explore the relationship of dietary fiber with all-cause and cardiovascular disease (CVD) mortality risk in patients with stroke.

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Background: Despite studies confirming that patients with inflammatory bowel disease (IBD) present with dyslipidaemia, the associations between IBD and the serum lipid profile have not been determined. The present study aimed to investigate the causal relationship between the serum lipid profile and IBD risk and elucidate the nature of the interactions between them.

Methods: Two-sample Mendelian randomisation (MR) analysis was performed to investigate the causal links between total cholesterol (TC), total triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (Apo A), apolipoprotein B (Apo B) and lipoprotein (a) (Lp(a)) and IBD.

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On-chip Fourier transform spectrometer (FTS) is a promising technology due to the compact size, low cost, and relatively high throughput. In this work, we design, fabricate, and characterize a Mach-Zehnder interferometer (MZI) FTS based on SU-8 polymer waveguide. The optical path length difference of MZI is tuned by a heater with a maximum power consumption of 2.

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Silent magnetic resonance angiography (S-MRA) is primarily utilized to assess the blood flow in aneurysms and parent vessels of treated intracranial aneurysms. This study aimed to compare the diagnostic value of S-MRA and three-dimensional time of flight (3D-TOF) MRA for unruptured intracranial aneurysms. We included patients diagnosed with unruptured intracranial aneurysms using digital subtraction angiography (DSA) who subsequently underwent S-MRA and 3D-TOF MRA.

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Adaptive learning capability of optoelectronic synaptic hardware holds promising application prospects in next generation artificial intelligence, and the development of biometric retina perception is sternly hampered by three crucial issues, including well-balance between excitatory and inhibitory, non-volatile multi-state storage, and optimal energy consumption. In this work, a novel CsAgBiBr/ZnO non-volatile optoelectronic synapse is proposed and successfully programmed with optical excitatory and electronic inhibitory in the light of dual-mechanism: Lead-free perovskite CsAgBiBr guarantees abundant photogenerated carrier concentration, and the process of carrier capture and release occurs in ZnO layer, which can collaboratively modulate various synaptic plasticity behaviors depending on distinct stimulus. Consequently, multi-bit storage is attained with the dual-mechanism non-volatile memory (DNVM) as a function of consecutive light spikes.

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In this paper, poly(diallyldimethylammonium chloride)(PDDA)/poly(sodium styrene sulfonate)(PSS) nanomembranes were deposited on the surface of long-period fiber gratings (LPFG) using the electrostatic layer-by-layer (LBL) assembly method, and the effect of NaCl on the modulation of LPFG double peaks by PDDA/PSS nanomembranes was investigated. The principle behind the emergence of double peaks was first explored using coupled mode theory, revealing that changes in the mode effective refractive index(RI) occur as the number of nanomembrane layers increases. The experimental results showed that under the conditions of PDDA with NaCl/PSS without NaCl and PDDA without NaCl/PSS with NaCl, double peaks do not appear in the spectra of LPFG as the number of thin film layers increases.

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Background: Cuproptosis is a unique form of cell death that is dependent on copper, which is fundamentally different from other recognized forms of cell death. However, the molecular and immune characteristics in cuproptosis-defined subgroups of cholangiocarcinoma (CCA) remain to be further illustrated.

Methods: We conducted a comprehensive investigation into the genetic and transcriptional variation, prognostic significance, and expression profiles of 16 cuproptosis-related genes (CRGs).

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Equity is a cornerstone of global climate policy, yet differing perspectives mean that international agreement on how to allocate mitigation efforts remains elusive. A rich literature informs this question, but a gap remains in approaches that appropriately consider non-CO emissions and their warming contributions. In this study, we address this gap and define a global warming budget applicable to all anthropogenic greenhouse gases that is allocated to countries based on principles drawn from international treaties and environmental law.

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Germplasm resources within the Medicago genus are highly regarded for their value as forage crops and their critical roles in nitrogen cycling, ecosystem restoration, and soil structure improvement. Therefore, understanding the diversity of seed morphology in this genus is essential for advancing its development and utilization. This study analyzed seed samples from 587 germplasm accessions representing 77 species within Medicago genus, as well as 32 accessions from 21 species within the closely related genus Trigonella.

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Aggregation-induced emission (AIE) or aggregation-induced emission enhancement (AIEE) has endowed gold species with responsive fluorescent properties, favoring their potential applications in sensing, imaging, and therapy. However, it remains an interesting challenge to fabricate fluorophores with both AIE and AIEE effects. Herein, we presented highly luminescent Au(I) thiolate nanocomplex-based biosensors with Zn induced-AIE and zeolite imidazolate framework (ZIF-8) induced-AIEE effects.

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New Onset Refractory Status Epilepticus (NORSE) is a rare and severe condition characterized by refractory seizures in individuals without a prior history of epilepsy. This case report describes a 37-year-old woman diagnosed with anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody-positive encephalitis-related NORSE. Her seizures were refractory to multiple interventions, including anti-seizure medications, anesthetics, immunotherapies, a ketogenic diet, and electroconvulsive therapy.

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Electronic skin is widely employed in multiple applications such as health monitoring, robot tactile perception, and bionic prosthetics. In this study, we fabricated millimeter-scale electronic skin featuring compact sensing units using the Boston Micro Fabrication S130 (a high-precision additive manufacturing device) and the template removal method. We used a gallium-based liquid metal and achieved an inner channel diameter of 0.

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Objective: Acute kidney injury (AKI) poses a lethal risk in intensive care unit (ICU) patients, where early detection is challenging. This study was to establish a prediction model for AKI 24 hours in advance for ICU patients and to help clinicians monitor patients at an early stage by key features.

Methods: In this study, the Medical Information Mart for Intensive Care (MIMIC) databases were used to construct a dataset of critically ill patients.

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Background: Burns and chronic ulcers may cause severe skin loss, leading to critical health issues like shock, infection, sepsis, and multiple organ failure. Effective healing of full-thickness wounds may be challenging, with traditional methods facing limitations due to tissue shortage, infection, and lack of structural support.

Methods: This study explored the combined use of gene transfection and dermal substitutes to improve wound healing.

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Background: Plants produce abundant natural products, among which are species-specific and diversified secondary metabolites that are essential for growth and development, as well as adaptation to adversity and ecology. Moreover, these secondary metabolites are extensively utilized in pharmaceuticals, fragrances, industrial materials, and more. WRKY transcription factors (TFs), as a family of TFs unique to plants, have significant functions in many plant life activities.

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Objective: This study aims to investigate the differences of clinical indices in HIV patients between three different first-line antiretroviral treatment strategies in Yunnan Province, China. Furthermore, the hematologic system, liver function, kidney function, blood lipid levels of HIV patients and its association with CD4+ count, CD8+ count, CD4/CD8 ratio and antiretroviral treatment were also assessed.

Methods: This retrospective cohort study included 81 participants who underwent highly active antiretroviral treatment from September 2009 to September 2019.

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The identification of allosteric binding sites forms a critical connection between structural and computational biology, substantially advancing the discovery of allosteric drugs. However, the prevailing strategies for allosteric drug development predominantly rely on high-throughput screening, which suffers from high failure rates due to a limited understanding of allosteric mechanisms. This review collects insights from case studies on allosteric mechanisms, protein structure databases and computation algorithm developments, aiming to enhance our comprehension of allostery and guide more effective allosteric drug development.

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