A typical multisite invasive infection caused by hvKP: A case report and literature review.

Rationale: Hypervirulent K. pneumoniae (hvKP) is a new variant of K. pneumoniae that can caused metastatic spreading by blood, including Splenic abscess, endogenous endophthalmitis, purulent meningitis.

Hsa_circ_0090002 regulates miR-186-5p/HECTD1 axis to mediate brain microvascular endothelial cell dysfunction.

Background: Ischemic injury is a common nervous disease associated with the dysfunction of human brain microvascular endothelial cells (HBMECs). Circular RNAs (circRNAs) have key roles in ischemic injury. This research aims to investigate the role and mechanism of circ_0090002 in ischemic injury.

Serum level of soluble CD14 subtype predicts long-term prognosis in sepsis patients with cardiac dysfunction.

Background: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and some sepsis patients will develop cardiac dysfunction. Sepsis-induced cardiac dysfunction (SICD) has been demonstrated to be a promising predictor of mortality, although the prediction of SICD itself remains unclear. Clinical studies have shown that soluble CD14 subtype (sCD14-ST) may be a useful predictor for sepsis.

Modulation of mitogen‑activated protein kinase attenuates sepsis‑induced acute lung injury in acute respiratory distress syndrome rats.

Sepsis is the most important predisposing cause inducing acute respiratory distress syndrome (ARDS); however, the mechanism of sepsis leading to the development of ARDS remains to be elucidated. Suppression of the mitogen‑activated protein kinase (MAPK) signal by blocking the phosphorylation of Jun N‑terminal kinase (JNK) and p38 in lung tissues could alleviate acute lung injury induced by sepsis. MAPK signaling may have a crucial role in development of the sepsis‑induced acute lung injury.

[Correlation factor analysis on constipation in long-term ventilated patients in intensive care unit: a prospective observational cohort study].

Objective: To explore the factors associated with delayed defecation in long-term ventilated patients in intensive care unit (ICU) and their potential effect on prognosis.

Methods: A prospective observational cohort study was conducted. The patients admitted to general ICU of the Affiliated Hospital of Qingdao University from October 1st in 2013 to September 30th in 2015 who underwent mechanical ventilation (MV) for ≥6 days were enrolled, and they were divided into early defecation group (< 6 days) and late defecation group (≥6 days).