Human umbilical cord mesenchymal stem cells regulate CD54 and CD105 in vascular endothelial cells and suppress inflammation in Kawasaki disease.

Objective: The objective was to evaluate the expression levels of CD31CD54 and CD31CD105 endothelial microparticles (EMPs) before and after intravenous immunoglobulin (IVIG) treatment of Kawasaki disease (KD). To explore the role of human umbilical cord mesenchymal stem cells (hucMSCs) in inhibiting endothelial inflammation in KD, the effects of hucMSCs on the expression of CD54 and CD105 in endothelial cells in KD were analyzed in vivo and in vitro.

Methods: The concentrations of IL-1β and VEGF in the peripheral blood of KD or healthy children were detected, and the distributions of CD31CD54 and CD31CD105 EMPs in platelet-poor plasma (PPP) were analyzed by flow cytometry.

Mechanism of HMGB1-RAGE in Kawasaki disease with coronary artery injury.

Background: Kawasaki disease (KD) is a common, yet unknown etiology disease in Asian countries, which causes acquired heart disease in childhood. It is characterized by an inflammatory acute febrile vasculitis of medium-sized arteries, particularly the coronary arteries. High-mobility group box-1 protein (HMGB1) is a non-histone chromosomal-binding protein present in the nucleus of eukaryotic cells, which contains 215 amino acid residues.

Geometric distortion evaluation using a multi-orientated water-phantom at 0.2 T MRI.

Magnetic Resonance Imaging (MRI) has been one of the most revolutionary medical imaging modalities in the past three decades. It has been recognized as a potential technique in the clinical diagnosis of diseases as well as tumor differentiation. Although MRI has now become the preferred choice in many clinical examinations, there are some drawbacks, which still limit its applications.